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Colonic crypt organization and tumorigenesis.
Humphries A, Wright NA. Humphries A, et al. Nat Rev Cancer. 2008 Jun;8(6):415-24. doi: 10.1038/nrc2392. Epub 2008 May 15. Nat Rev Cancer. 2008. PMID: 18480839 Review.
The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.
Pollard P, Deheragoda M, Segditsas S, Lewis A, Rowan A, Howarth K, Willis L, Nye E, McCart A, Mandir N, Silver A, Goodlad R, Stamp G, Cockman M, East P, Spencer-Dene B, Poulsom R, Wright N, Tomlinson I. Pollard P, et al. Gastroenterology. 2009 Jun;136(7):2204-2213.e1-13. doi: 10.1053/j.gastro.2009.02.058. Epub 2009 Feb 25. Gastroenterology. 2009. PMID: 19248780
Trefoil factor family peptides in normal and diseased human pancreas.
Guppy NJ, El-Bahrawy ME, Kocher HM, Fritsch K, Qureshi YA, Poulsom R, Jeffery RE, Wright NA, Otto WR, Alison MR. Guppy NJ, et al. Pancreas. 2012 Aug;41(6):888-96. doi: 10.1097/MPA.0b013e31823c9ec5. Pancreas. 2012. PMID: 22286382
Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia.
Alferez DG, Goodlad RA, Odedra R, Sini P, Crafter C, Ryan AJ, Wedge SR, Wright NA, Anderson E, Wilkinson RW. Alferez DG, et al. Int J Oncol. 2012 Oct;41(4):1475-85. doi: 10.3892/ijo.2012.1580. Epub 2012 Jul 31. Int J Oncol. 2012. PMID: 22858681
Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis.
March HN, Rust AG, Wright NA, ten Hoeve J, de Ridder J, Eldridge M, van der Weyden L, Berns A, Gadiot J, Uren A, Kemp R, Arends MJ, Wessels LF, Winton DJ, Adams DJ. March HN, et al. Nat Genet. 2011 Nov 6;43(12):1202-9. doi: 10.1038/ng.990. Nat Genet. 2011. PMID: 22057237 Free PMC article.
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.
Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB. Wong VW, et al. Nat Cell Biol. 2012 Mar 4;14(4):401-8. doi: 10.1038/ncb2464. Nat Cell Biol. 2012. PMID: 22388892 Free PMC article.
Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission.
Preston SL, Wong WM, Chan AO, Poulsom R, Jeffery R, Goodlad RA, Mandir N, Elia G, Novelli M, Bodmer WF, Tomlinson IP, Wright NA. Preston SL, et al. Cancer Res. 2003 Jul 1;63(13):3819-25. Cancer Res. 2003. PMID: 12839979
Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts.
Direkze NC, Hodivala-Dilke K, Jeffery R, Hunt T, Poulsom R, Oukrif D, Alison MR, Wright NA. Direkze NC, et al. Cancer Res. 2004 Dec 1;64(23):8492-5. doi: 10.1158/0008-5472.CAN-04-1708. Cancer Res. 2004. PMID: 15574751
Bone marrow cells in murine colitis: multi-signal analysis confirms pericryptal myofibroblast engraftment without epithelial involvement.
Lee CY, Jeffery R, Hutchinson G, Alison MR, Poulsom R, Wright NA, Otto WR. Lee CY, et al. PLoS One. 2011;6(10):e26082. doi: 10.1371/journal.pone.0026082. Epub 2011 Oct 13. PLoS One. 2011. PMID: 22022515 Free PMC article.
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