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A pharmacodynamic explanation for the rapid onset/offset of rapacuronium bromide.
Wright PM, Brown R, Lau M, Fisher DM. Wright PM, et al. Anesthesiology. 1999 Jan;90(1):16-23. doi: 10.1097/00000542-199901000-00005. Anesthesiology. 1999. PMID: 9915308 Clinical Trial.
Temperature-dependent pharmacokinetics and pharmacodynamics of vecuronium.
Caldwell JE, Heier T, Wright PM, Lin S, McCarthy G, Szenohradszky J, Sharma ML, Hing JP, Schroeder M, Sessler DI. Caldwell JE, et al. Among authors: wright pm. Anesthesiology. 2000 Jan;92(1):84-93. doi: 10.1097/00000542-200001000-00018. Anesthesiology. 2000. PMID: 10638903 Clinical Trial.
Influence of renal failure on the pharmacokinetics and neuromuscular effects of a single dose of rapacuronium bromide.
Szenohradszky J, Caldwell JE, Wright PM, Brown R, Lau M, Luks AM, Fisher DM. Szenohradszky J, et al. Among authors: wright pm. Anesthesiology. 1999 Jan;90(1):24-35. doi: 10.1097/00000542-199901000-00006. Anesthesiology. 1999. PMID: 9915309 Clinical Trial.
Do the pharmacokinetics of vecuronium change during prolonged administration in critically ill patients?
Segredo V, Caldwell JE, Wright PM, Sharma ML, Gruenke LD, Miller RD. Segredo V, et al. Among authors: wright pm. Br J Anaesth. 1998 Jun;80(6):715-9. doi: 10.1093/bja/80.6.715. Br J Anaesth. 1998. PMID: 9771295
Are plasma concentration values necessary for pharmacodynamic modeling of muscle relaxants?
Fisher DM, Wright PM. Fisher DM, et al. Among authors: wright pm. Anesthesiology. 1997 Mar;86(3):567-75. doi: 10.1097/00000542-199703000-00008. Anesthesiology. 1997. PMID: 9066322
Pharmacodynamic modeling of vecuronium-induced twitch depression. Rapid plasma-effect site equilibration explains faster onset at resistant laryngeal muscles than at the adductor pollicis.
Fisher DM, Szenohradszky J, Wright PM, Lau M, Brown R, Sharma M. Fisher DM, et al. Among authors: wright pm. Anesthesiology. 1997 Mar;86(3):558-66. doi: 10.1097/00000542-199703000-00007. Anesthesiology. 1997. PMID: 9066321
Improving the design of muscle relaxant studies. Stabilization period and tetanic recruitment.
Lee GC, Iyengar S, Szenohradszky J, Caldwell JE, Wright PM, Brown R, Lau M, Luks A, Fisher DM. Lee GC, et al. Among authors: wright pm. Anesthesiology. 1997 Jan;86(1):48-54. doi: 10.1097/00000542-199701000-00008. Anesthesiology. 1997. PMID: 9009939
Pharmacokinetics and pharmacodynamics of cisatracurium in young and elderly adult patients.
Sorooshian SS, Stafford MA, Eastwood NB, Boyd AH, Hull CJ, Wright PM. Sorooshian SS, et al. Among authors: wright pm. Anesthesiology. 1996 May;84(5):1083-91. doi: 10.1097/00000542-199605000-00010. Anesthesiology. 1996. PMID: 8624002
Onset and duration of rocuronium and succinylcholine at the adductor pollicis and laryngeal adductor muscles in anesthetized humans.
Wright PM, Caldwell JE, Miller RD. Wright PM, et al. Anesthesiology. 1994 Nov;81(5):1110-5. doi: 10.1097/00000542-199411000-00004. Anesthesiology. 1994. PMID: 7978469 Clinical Trial.
The pharmacodynamics and pharmacokinetics of the metabolite 3-desacetylvecuronium (ORG 7268) and its parent compound, vecuronium, in human volunteers.
Caldwell JE, Szenohradszky J, Segredo V, Wright PM, McLoughlin C, Sharma ML, Gruenke LD, Fisher DM, Miller RD. Caldwell JE, et al. Among authors: wright pm. J Pharmacol Exp Ther. 1994 Sep;270(3):1216-22. J Pharmacol Exp Ther. 1994. PMID: 7932174 Clinical Trial.
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