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Hallmarks of telomeres in ageing research.
Shay JW, Wright WE. Shay JW, et al. J Pathol. 2007 Jan;211(2):114-23. doi: 10.1002/path.2090. J Pathol. 2007. PMID: 17200948 Review.
Comparison of telomere length measurement methods.
Lai TP, Wright WE, Shay JW. Lai TP, et al. Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741):20160451. doi: 10.1098/rstb.2016.0451. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 29335378 Free PMC article. Review.
For each method, we will cover information about validation studies, including reproducibility in independent laboratories, accuracy, reliability and sensitivity for measuring not only the average but also the shortest telomeres. ...
For each method, we will cover information about validation studies, including reproducibility in independent laboratories, accuracy, …
Telomere dynamics in macaques and humans.
Gardner JP, Kimura M, Chai W, Durrani JF, Tchakmakjian L, Cao X, Lu X, Li G, Peppas AP, Skurnick J, Wright WE, Shay JW, Aviv A. Gardner JP, et al. J Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):367-74. doi: 10.1093/gerona/62.4.367. J Gerontol A Biol Sci Med Sci. 2007. PMID: 17452729
We examined telomere parameters in tissues of young and old Macaca fascicularis and compared them with several tissues from humans. ...We conclude that factors that modify telomere attrition and aging in humans may also operate in the macaque....
We examined telomere parameters in tissues of young and old Macaca fascicularis and compared them with several tissues from humans. .
H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents.
Vaughan MB, Ramirez RD, Andrews CM, Wright WE, Shay JW. Vaughan MB, et al. PLoS One. 2009 Nov 19;4(11):e7908. doi: 10.1371/journal.pone.0007908. PLoS One. 2009. PMID: 19936293 Free PMC article.
In the present studies we sought to determine whether expression of H-ras in skin keratinocytes would affect these parameters during the establishment and maintenance of an in vitro skin equivalent. ...
In the present studies we sought to determine whether expression of H-ras in skin keratinocytes would affect these parameters during …
Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro.
Roig AI, Eskiocak U, Hight SK, Kim SB, Delgado O, Souza RF, Spechler SJ, Wright WE, Shay JW. Roig AI, et al. Gastroenterology. 2010 Mar;138(3):1012-21.e1-5. doi: 10.1053/j.gastro.2009.11.052. Epub 2009 Dec 4. Gastroenterology. 2010. PMID: 19962984
We sought to immortalize human colon biopsy-derived cells expressing stem cell markers and retaining multilineage epithelial differentiation capability. ...CONCLUSIONS: We established immortalized HCECs that are capable of self-renewal and multilineage differentiati
We sought to immortalize human colon biopsy-derived cells expressing stem cell markers and retaining multilineage epithelial differen
Generation of digoxigenin-incorporated probes to enhance DNA detection sensitivity.
Lai TP, Wright WE, Shay JW. Lai TP, et al. Biotechniques. 2016 Jun 1;60(6):306-9. doi: 10.2144/000114427. eCollection 2016. Biotechniques. 2016. PMID: 27286808
Here, we describe a non-radioactive labeling method that uses 3' fill-in combined with lambda exonuclease digestion to incorporate one or more digoxigenin (DIG) molecules into bridged nucleic acid (BNA)-containing oligonucleotides (ONTs). Using our method, we were a …
Here, we describe a non-radioactive labeling method that uses 3' fill-in combined with lambda exonuclease digestion to incorporate on …
Facioscapulohumeral muscular dystrophy: Are telomeres the end of the story?
Stadler G, King OD, Robin JD, Shay JW, Wright WE. Stadler G, et al. Rare Dis. 2013 Aug 14;1:e26142. doi: 10.4161/rdis.26142. eCollection 2013. Rare Dis. 2013. PMID: 25003004 Free PMC article.
We recently showed in a cell culture model that DUX4 expression is regulated by telomere length, suggesting that telomere shortening during aging may be partially responsible for the delayed onset and progressive nature of FSHD. We here put our data in the context o
We recently showed in a cell culture model that DUX4 expression is regulated by telomere length, suggesting that telomere shortening
Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.
Robin JD, Ludlow AT, Batten K, Magdinier F, Stadler G, Wagner KR, Shay JW, Wright WE. Robin JD, et al. Genes Dev. 2014 Nov 15;28(22):2464-76. doi: 10.1101/gad.251041.114. Genes Dev. 2014. PMID: 25403178 Free PMC article.
Here we describe how telomere length regulates gene expression long before telomeres become short enough to produce a DNA damage response (senescence). ...We demonstrate that chromosome looping brings the telomere close to genes up to 10 Mb away from the telomere wh …
Here we describe how telomere length regulates gene expression long before telomeres become short enough to produce a DNA damage resp …
CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation.
El-Ashmawy M, Delgado O, Cardentey A, Wright WE, Shay JW. El-Ashmawy M, et al. PLoS One. 2014 Dec 23;9(12):e115600. doi: 10.1371/journal.pone.0115600. eCollection 2014. PLoS One. 2014. PMID: 25536195 Free PMC article.
In the present series of experiments, we determined if CDDO-Me can be used as a radioprotector in normal non-cancerous human lung and breast epithelial cells, in comparison to lung and breast cancer cell lines. ...
In the present series of experiments, we determined if CDDO-Me can be used as a radioprotector in normal non-cancerous human lung and …
Alternative splicing regulation of telomerase: a new paradigm?
Wong MS, Wright WE, Shay JW. Wong MS, et al. Trends Genet. 2014 Oct;30(10):430-8. doi: 10.1016/j.tig.2014.07.006. Epub 2014 Aug 26. Trends Genet. 2014. PMID: 25172021 Free PMC article.
Here we review work showing that hTERT expression is in part regulated by atypical alternative splicing, perhaps due to its exceptionally low expression level. We propose that these differential regulatory mechanisms may be widely applicable to other genes and may p …
Here we review work showing that hTERT expression is in part regulated by atypical alternative splicing, perhaps due to its exception …
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