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The role of low-calorie diets and intermittent fasting in the treatment of obesity and type-2 diabetes.
Zubrzycki A, Cierpka-Kmiec K, Kmiec Z, Wronska A. Zubrzycki A, et al. Among authors: wronska a. J Physiol Pharmacol. 2018 Oct;69(5). doi: 10.26402/jpp.2018.5.02. Epub 2019 Jan 21. J Physiol Pharmacol. 2018. PMID: 30683819 Review.
Obesity is a condition associated with an increased risk of metabolic disorders, and in particular of type-2 diabetes (T2D). ...A major therapeutic goal in T2D is to control blood glucose levels, which can be achieved by pharmacological and nonpharmacological measur …
Obesity is a condition associated with an increased risk of metabolic disorders, and in particular of type-2 diabetes (T2D). ...A
Structural and biochemical characteristics of various white adipose tissue depots.
Wronska A, Kmiec Z. Wronska A, et al. Acta Physiol (Oxf). 2012 Jun;205(2):194-208. doi: 10.1111/j.1748-1716.2012.02409.x. Epub 2012 Feb 1. Acta Physiol (Oxf). 2012. PMID: 22226221 Review.
It is now widely accepted that white adipose tissue (WAT) is not merely a fuel storage organ, but also a key component of metabolic homoeostatic mechanisms. Apart from its major role in lipid and glucose metabolism, adipose tissue is also involved in a wide a …
It is now widely accepted that white adipose tissue (WAT) is not merely a fuel storage organ, but also a key component of meta …
Short-term calorie restriction and refeeding differently affect lipogenic enzymes in major white adipose tissue depots of young and old rats.
Wronska A, Sledzinski T, Goyke E, Lawniczak A, Wierzbicki P, Kmiec Z. Wronska A, et al. J Physiol Pharmacol. 2014 Feb;65(1):117-26. J Physiol Pharmacol. 2014. PMID: 24622836
The animals were subjected to a 40% calorie restricted diet (i.e. 40% lower food supply than of control rats) for 30 days, and then re-fed for 0, 2, or 4 days. ...A prominent age-related decrease of ACL and FAS activities, but not of G6PD activity, was found in all …
The animals were subjected to a 40% calorie restricted diet (i.e. 40% lower food supply than of control rats) for 30 days, and then r …
White Adipose Tissue Depot-Specific Activity of Lipogenic Enzymes in Response to Fasting and Refeeding in Young and Old Rats.
Wronska A, Lawniczak A, Wierzbicki PM, Goyke E, Sledzinski T, Kmiec Z. Wronska A, et al. Gerontology. 2015;61(5):448-55. doi: 10.1159/000371578. Epub 2015 Feb 20. Gerontology. 2015. PMID: 25721559
BACKGROUND: Although the heterogeneity of white adipose tissue (WAT) in different anatomical sites is a well-known phenomenon, there are scarce data on aging-associated metabolic alterations in various WAT depots. ...
BACKGROUND: Although the heterogeneity of white adipose tissue (WAT) in different anatomical sites is a well-known phenomenon, there …
Age-Related Changes in Sirtuin 7 Expression in Calorie-Restricted and Refed Rats.
Wronska A, Lawniczak A, Wierzbicki PM, Kmiec Z. Wronska A, et al. Gerontology. 2016;62(3):304-10. doi: 10.1159/000441603. Epub 2015 Nov 24. Gerontology. 2016. PMID: 26595207
In vitro generation of pancreatic β-cells for diabetes treatment. I. β-like cells derived from human pluripotent stem cells.
Cierpka-Kmiec K, Wronska A, Kmiec Z. Cierpka-Kmiec K, et al. Among authors: wronska a. Folia Histochem Cytobiol. 2019;57(1):1-14. doi: 10.5603/FHC.a2019.0001. Epub 2019 Mar 14. Folia Histochem Cytobiol. 2019. PMID: 30869153 Review.
Diabetes mellitus is a chronic disease that affects hundreds of millions of people worldwide. Type 1 diabetes (T1D) is characterized by the lack of pancreatic β-cells that had been destroyed as a result of an autoimmune response. Therefore, in patients with T1D, the …
Diabetes mellitus is a chronic disease that affects hundreds of millions of people worldwide. Type 1 diabetes (T1D) is characterized …
Identification of a suitable qPCR reference gene in metastatic clear cell renal cell carcinoma.
Wierzbicki PM, Klacz J, Rybarczyk A, Slebioda T, Stanislawowski M, Wronska A, Kowalczyk A, Matuszewski M, Kmiec Z. Wierzbicki PM, et al. Among authors: wronska a. Tumour Biol. 2014 Dec;35(12):12473-87. doi: 10.1007/s13277-014-2566-9. Epub 2014 Sep 16. Tumour Biol. 2014. PMID: 25225161 Free PMC article.
Decreased expression of RASSF1A tumor suppressor gene is associated with worse prognosis in clear cell renal cell carcinoma.
Klacz J, Wierzbicki PM, Wronska A, Rybarczyk A, Stanislawowski M, Slebioda T, Olejniczak A, Matuszewski M, Kmiec Z. Klacz J, et al. Among authors: wronska a. Int J Oncol. 2016 Jan;48(1):55-66. doi: 10.3892/ijo.2015.3251. Epub 2015 Nov 18. Int J Oncol. 2016. PMID: 26648328 Free PMC article.
RASSF1, with its isoforms RASSF1A and RASSF1C, is a tumor suppressor gene which has not been fully analyzed in ccRCC yet. The epigenetic downregulation of RASSF1A is commonly associated with promoter hypermethylation. ...We conclude that RASSF1C gene is not involved in ccR …
RASSF1, with its isoforms RASSF1A and RASSF1C, is a tumor suppressor gene which has not been fully analyzed in ccRCC yet. The epigene …
Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome.
Rybarczyk A, Klacz J, Wronska A, Matuszewski M, Kmiec Z, Wierzbicki PM. Rybarczyk A, et al. Among authors: wronska a. Oncol Rep. 2017 Jul;38(1):427-439. doi: 10.3892/or.2017.5642. Epub 2017 May 15. Oncol Rep. 2017. PMID: 28504812
Yes-associated protein 1 (YAP1) protein is a nuclear effector of the Hippo pathway and acts as a transcriptional co-activator of genes involved in the processes of growth and development of tissues. ...Measurement of YAP1 mRNA levels in paired tumor-normal kidney ti …
Yes-associated protein 1 (YAP1) protein is a nuclear effector of the Hippo pathway and acts as a transcriptional co-activator …
Decreased expression of p73 in colorectal cancer.
Kotulak A, Wronska A, Kobiela J, Godlewski J, Stanislawowski M, Wierzbicki P. Kotulak A, et al. Among authors: wronska a. Folia Histochem Cytobiol. 2016;54(3):166-170. doi: 10.5603/FHC.a2016.0018. Epub 2016 Sep 21. Folia Histochem Cytobiol. 2016. PMID: 27654017
RESULTS: We found a 37% decrease in the level of p73a mRNA in neoplastically changed (tumor) compared with unchanged normal colon tissue from the surgical margin (p = 0.041). ...CONCLUSIONS: The obtained results suggest that the p73 gene may play a role as a
RESULTS: We found a 37% decrease in the level of p73a mRNA in neoplastically changed (tumor) compared with unchanged normal colon tis …
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