Wu CY - Search Results

1

Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice.

Wu CY, Tso SC, Chuang JL, Gui WJ, Lou M, Sharma G, Khemtong C, Qi X, Wynn RM, Chuang DT. Wu CY, et al. Mol Metab. 2018 Jun;12:12-24. doi: 10.1016/j.molmet.2018.03.014. Epub 2018 Mar 31. Mol Metab. 2018. PMID: 29656110 Free PMC article.

2

Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket.

Tso SC, Qi X, Gui WJ, Wu CY, Chuang JL, Wernstedt-Asterholm I, Morlock LK, Owens KR, Scherer PE, Williams NS, Tambar UK, Wynn RM, Chuang DT. Tso SC, et al. Among authors: wu cy. J Biol Chem. 2014 Feb 14;289(7):4432-43. doi: 10.1074/jbc.M113.533885. Epub 2013 Dec 19. J Biol Chem. 2014. PMID: 24356970 Free PMC article.

3

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.

Tso SC, Lou M, Wu CY, Gui WJ, Chuang JL, Morlock LK, Williams NS, Wynn RM, Qi X, Chuang DT. Tso SC, et al. Among authors: wu cy. J Med Chem. 2017 Feb 9;60(3):1142-1150. doi: 10.1021/acs.jmedchem.6b01540. Epub 2017 Jan 31. J Med Chem. 2017. PMID: 28085286 Free PMC article.

4

A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity.

Wu CY, Satapati S, Gui W, Wynn RM, Sharma G, Lou M, Qi X, Burgess SC, Malloy C, Khemtong C, Sherry AD, Chuang DT, Merritt ME. Wu CY, et al. J Biol Chem. 2018 Jun 22;293(25):9604-9613. doi: 10.1074/jbc.RA118.002838. Epub 2018 May 8. J Biol Chem. 2018. PMID: 29739849 Free PMC article.

5

Real-time hyperpolarized ¹³C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4-double knockout mouse livers.

Sharma G, Wu CY, Wynn RM, Gui W, Malloy CR, Sherry AD, Chuang DT, Khemtong C. Sharma G, et al. Among authors: wu cy. Sci Rep. 2019 Nov 11;9(1):16480. doi: 10.1038/s41598-019-52952-6. Sci Rep. 2019. PMID: 31712597 Free PMC article.

6

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance.

Zhou M, Shao J, Wu CY, Shu L, Dong W, Liu Y, Chen M, Wynn RM, Wang J, Wang J, Gui WJ, Qi X, Lusis AJ, Li Z, Wang W, Ning G, Yang X, Chuang DT, Wang Y, Sun H. Zhou M, et al. Among authors: wu cy. Diabetes. 2019 Sep;68(9):1730-1746. doi: 10.2337/db18-0927. Epub 2019 Jun 5. Diabetes. 2019. PMID: 31167878 Free PMC article.

7

Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase.

Tso SC, Gui WJ, Wu CY, Chuang JL, Qi X, Skvora KJ, Dork K, Wallace AL, Morlock LK, Lee BH, Hutson SM, Strom SC, Williams NS, Tambar UK, Wynn RM, Chuang DT. Tso SC, et al. Among authors: wu cy. J Biol Chem. 2014 Jul 25;289(30):20583-93. doi: 10.1074/jbc.M114.569251. J Biol Chem. 2014. PMID: 24895126 Free PMC article.

8

Validation of SV2A-Targeted PET Imaging for Noninvasive Assessment of Neuroendocrine Differentiation in Prostate Cancer.

Guan B, Zhou N, Wu CY, Li S, Chen YA, Debnath S, Hofstad M, Ma S, Raj GV, He D, Hsieh JT, Huang Y, Hao G, Sun X. Guan B, et al. Among authors: wu cy. Int J Mol Sci. 2021 Dec 3;22(23):13085. doi: 10.3390/ijms222313085. Int J Mol Sci. 2021. PMID: 34884893 Free PMC article.

9

Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin.

Wu CY, Feng Y, Cardenas ER, Williams N, Floreancig PE, De Brabander JK, Roth MG. Wu CY, et al. J Am Chem Soc. 2012 Nov 21;134(46):18998-9003. doi: 10.1021/ja3057002. Epub 2012 Nov 13. J Am Chem Soc. 2012. PMID: 23088155 Free PMC article.

10

Radiolabeling strategies and pharmacokinetic studies for metal based nanotheranostics.

Ranjbar Bahadori S, Mulgaonkar A, Hart R, Wu CY, Zhang D, Pillai A, Hao Y, Sun X. Ranjbar Bahadori S, et al. Among authors: wu cy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Mar;13(2):e1671. doi: 10.1002/wnan.1671. Epub 2020 Oct 12. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021. PMID: 33047504 Review.

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