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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 1
1968 1
1969 3
1971 2
1972 1
1973 2
1974 5
1975 4
1976 2
1977 2
1978 6
1979 1
1980 5
1981 8
1982 17
1983 18
1984 21
1985 33
1986 23
1987 26
1988 27
1989 23
1990 41
1991 51
1992 65
1993 79
1994 77
1995 91
1996 93
1997 103
1998 126
1999 117
2000 146
2001 159
2002 157
2003 171
2004 229
2005 259
2006 285
2007 301
2008 388
2009 454
2010 490
2011 615
2012 630
2013 713
2014 735
2015 806
2016 854
2017 891
2018 981
2019 1054
2020 217
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10,469 results
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Page 1
DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation.
Wu G, et al. Proc Natl Acad Sci U S A 2019. PMID 31548374 Free PMC article.
G-quadruplexes (G4) are noncanonical secondary structures formed in guanine-rich DNA and RNA sequences. MYC, one of the most critical oncogenes, forms a DNA G4 in its proximal promoter region (MycG4) that functions as a transcriptional silencer. ...The chromatin binding sites of DDX5 are G-rich sequences. In cancer cells, DDX5 is enriched at the MYC promoter and activates MYC transcription. ...
G-quadruplexes (G4) are noncanonical secondary structures formed in guanine-rich DNA and RNA sequences. MYC, one of the most critical
Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease
Hong J, et al. Diabetes Care 2013 - Clinical Trial. Among authors: Wu G. PMID 23230096 Free PMC article.
Participants were randomly assigned to receive either glipizide (30 mg daily) or metformin (1.5 g daily) for 3 years. The primary end points were times to the composite of recurrent cardiovascular events, including death from a cardiovascular cause, death from any cause, nonfatal myocardial infarction, nonfatal stroke, or arterial revascularization. ...
Participants were randomly assigned to receive either glipizide (30 mg daily) or metformin (1.5 g daily) for 3 years. The primary end …
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Tu N, et al. AJNR Am J Neuroradiol 2019. Among authors: Wu G. PMID 31467243
Electrophoretic Mobility Shift Assay and Dimethyl Sulfate Footprinting for Characterization of G-Quadruplexes and G-Quadruplex-Protein Complexes.
Onel B, et al. Methods Mol Biol 2019. Among authors: Wu G. PMID 31444751
DMS footprinting can also reveal important information in G-quadruplex-protein complexes on protein contacts and regional changes in DNA G-quadruplex upon protein binding. In this paper, we will provide a detailed protocol for the EMSA and DMS footprinting assays for characterization of G-quadruplexes and G-quadruplex-protein complexes. ...
DMS footprinting can also reveal important information in G-quadruplex-protein complexes on protein contacts and regional changes in …
A DNA Polymerase Stop Assay for Characterization of G-Quadruplex Formation and Identification of G-Quadruplex-Interactive Compounds.
Wu G and Han H. Methods Mol Biol 2019. PMID 31444752
Therefore, DNA G-quadruplexes are thought to be attractive targets for new anticancer therapies. In this chapter, we describe step by step a DNA polymerase extension method for the characterization of G-quadruplex formation and identification of G-quadruplex-interactive compounds. ...Results from the DNA polymerase stop assay can provide the basis for further studies aimed at elucidating the major G-quadruplexes formed by sequences consisting of more than four runs of contiguous guanines, as well as the specificity of G-quadruplex-interactive molecules in binding different G-quadruplex topologies....
Therefore, DNA G-quadruplexes are thought to be attractive targets for new anticancer therapies. In this chapter, we describe step by …
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