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Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.
Groh V, Wu J, Yee C, Spies T. Groh V, et al. Among authors: wu j. Nature. 2002 Oct 17;419(6908):734-8. doi: 10.1038/nature01112. Nature. 2002. PMID: 12384702
T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial gamma delta T cells.
Wu J, Groh V, Spies T. Wu J, et al. J Immunol. 2002 Aug 1;169(3):1236-40. doi: 10.4049/jimmunol.169.3.1236. J Immunol. 2002. PMID: 12133944
Intracellular retention of the MHC class I-related chain B ligand of NKG2D by the human cytomegalovirus UL16 glycoprotein.
Wu J, Chalupny NJ, Manley TJ, Riddell SR, Cosman D, Spies T. Wu J, et al. J Immunol. 2003 Apr 15;170(8):4196-200. doi: 10.4049/jimmunol.170.8.4196. J Immunol. 2003. PMID: 12682252
Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer.
Wu JD, Higgins LM, Steinle A, Cosman D, Haugk K, Plymate SR. Wu JD, et al. J Clin Invest. 2004 Aug;114(4):560-8. doi: 10.1172/JCI22206. J Clin Invest. 2004. PMID: 15314693 Free PMC article.
Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-gamma expression, and NK cells: a physiological role for testosterone and/or its metabolites.
Page ST, Plymate SR, Bremner WJ, Matsumoto AM, Hess DL, Lin DW, Amory JK, Nelson PS, Wu JD. Page ST, et al. Among authors: wu jd. Am J Physiol Endocrinol Metab. 2006 May;290(5):E856-63. doi: 10.1152/ajpendo.00484.2005. Epub 2005 Dec 13. Am J Physiol Endocrinol Metab. 2006. PMID: 16352669 Clinical Trial.
Interaction of IGF signaling and the androgen receptor in prostate cancer progression.
Wu JD, Haugk K, Woodke L, Nelson P, Coleman I, Plymate SR. Wu JD, et al. J Cell Biochem. 2006 Oct 1;99(2):392-401. doi: 10.1002/jcb.20929. J Cell Biochem. 2006. PMID: 16639715 Review.
Obstructing shedding of the immunostimulatory MHC class I chain-related gene B prevents tumor formation.
Wu JD, Atteridge CL, Wang X, Seya T, Plymate SR. Wu JD, et al. Clin Cancer Res. 2009 Jan 15;15(2):632-40. doi: 10.1158/1078-0432.CCR-08-1305. Clin Cancer Res. 2009. PMID: 19147769 Free PMC article.
An six-amino acid motif in the alpha3 domain of MICA is the cancer therapeutic target to inhibit shedding.
Wang X, Lundgren AD, Singh P, Goodlett DR, Plymate SR, Wu JD. Wang X, et al. Among authors: wu jd. Biochem Biophys Res Commun. 2009 Sep 25;387(3):476-81. doi: 10.1016/j.bbrc.2009.07.062. Epub 2009 Jul 16. Biochem Biophys Res Commun. 2009. PMID: 19615970 Free PMC article.
The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases.
Liu G, Atteridge CL, Wang X, Lundgren AD, Wu JD. Liu G, et al. Among authors: wu jd. J Immunol. 2010 Apr 1;184(7):3346-50. doi: 10.4049/jimmunol.0903789. Epub 2010 Mar 5. J Immunol. 2010. PMID: 20208009 Free PMC article.
Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype.
Xiao G, Wang X, Sheng J, Lu S, Yu X, Wu JD. Xiao G, et al. Among authors: wu jd. J Hematol Oncol. 2015 Feb 20;8:13. doi: 10.1186/s13045-015-0110-z. J Hematol Oncol. 2015. PMID: 25887583 Free PMC article.
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