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Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers.
Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. Kayed R, et al. Among authors: wu j. Mol Neurodegener. 2007 Sep 26;2:18. doi: 10.1186/1750-1326-2-18. Mol Neurodegener. 2007. PMID: 17897471 Free PMC article.
Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.
Rasool S, Albay R 3rd, Martinez-Coria H, Breydo L, Wu J, Milton S, Misra S, Tran A, Pensalfini A, Laferla F, Kayed R, Glabe CG. Rasool S, et al. Among authors: wu j. Mol Neurodegener. 2012 Aug 6;7:37. doi: 10.1186/1750-1326-7-37. Mol Neurodegener. 2012. PMID: 22866920 Free PMC article.
Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques.
Pensalfini A, Albay R 3rd, Rasool S, Wu JW, Hatami A, Arai H, Margol L, Milton S, Poon WW, Corrada MM, Kawas CH, Glabe CG. Pensalfini A, et al. Neurobiol Dis. 2014 Nov;71:53-61. doi: 10.1016/j.nbd.2014.07.011. Epub 2014 Aug 1. Neurobiol Dis. 2014. PMID: 25092575 Free PMC article.
Structural differences between amyloid beta oligomers.
Breydo L, Kurouski D, Rasool S, Milton S, Wu JW, Uversky VN, Lednev IK, Glabe CG. Breydo L, et al. Biochem Biophys Res Commun. 2016 Sep 2;477(4):700-705. doi: 10.1016/j.bbrc.2016.06.122. Epub 2016 Jun 27. Biochem Biophys Res Commun. 2016. PMID: 27363332
Α-synuclein misfolding and Parkinson's disease.
Breydo L, Wu JW, Uversky VN. Breydo L, et al. Biochim Biophys Acta. 2012 Feb;1822(2):261-85. doi: 10.1016/j.bbadis.2011.10.002. Epub 2011 Oct 12. Biochim Biophys Acta. 2012. PMID: 22024360 Free article. Review.
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