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Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy.
Thannickal TC, John J, Shan L, Swaab DF, Wu MF, Ramanathan L, McGregor R, Chew KT, Cornford M, Yamanaka A, Inutsuka A, Fronczek R, Lammers GJ, Worley PF, Siegel JM. Thannickal TC, et al. Among authors: wu mf. Sci Transl Med. 2018 Jun 27;10(447):eaao4953. doi: 10.1126/scitranslmed.aao4953. Sci Transl Med. 2018. PMID: 29950444
Release of hypocretin (orexin) during waking and sleep states.
Kiyashchenko LI, Mileykovskiy BY, Maidment N, Lam HA, Wu MF, John J, Peever J, Siegel JM. Kiyashchenko LI, et al. Among authors: wu mf. J Neurosci. 2002 Jul 1;22(13):5282-6. doi: 10.1523/JNEUROSCI.22-13-05282.2002. J Neurosci. 2002. PMID: 12097478 Free PMC article.
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