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A JNK-dependent pathway is required for TNFalpha-induced apoptosis.
Deng Y, Ren X, Yang L, Lin Y, Wu X. Deng Y, et al. Cell. 2003 Oct 3;115(1):61-70. doi: 10.1016/s0092-8674(03)00757-8. Cell. 2003. PMID: 14532003
Bax and BH3-domain-only proteins in p53-mediated apoptosis.
Wu X, Deng Y. Wu X, et al. Front Biosci. 2002 Jan 1;7:d151-6. Front Biosci. 2002. PMID: 11779719 Review.
Lung-cancer chemoprevention by induction of synthetic lethality in mutant KRAS premalignant cells in vitro and in vivo.
Huang S, Ren X, Wang L, Zhang L, Wu X. Huang S, et al. Cancer Prev Res (Phila). 2011 May;4(5):666-73. doi: 10.1158/1940-6207.CAPR-10-0235. Cancer Prev Res (Phila). 2011. PMID: 21543344
Smac overcame KRAS-induced cell-survival signaling by antagonizing X-linked inhibitor of apoptosis protein (XIAP). Therefore, the combination of TRAIL and a small molecule mimic of Smac induced apoptosis specifically in mutant KRAS cells without harming normal cells. ...
Smac overcame KRAS-induced cell-survival signaling by antagonizing X-linked inhibitor of apoptosis protein (XIAP). Therefore, the com …
Bypass NFkappaB-mediated survival pathways by TRAIL and Smac.
Ren X, Xu Z, Myers JN, Wu X. Ren X, et al. Cancer Biol Ther. 2007 Jul;6(7):1031-5. doi: 10.4161/cbt.6.7.4206. Cancer Biol Ther. 2007. PMID: 17611406
Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis.
Zhang L, Ren X, Alt E, Bai X, Huang S, Xu Z, Lynch PM, Moyer MP, Wen XF, Wu X. Zhang L, et al. Nature. 2010 Apr 15;464(7291):1058-61. doi: 10.1038/nature08871. Epub 2010 Mar 28. Nature. 2010. PMID: 20348907 Free PMC article.
Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death.
Johnson MD, Wu X, Aithmitti N, Morrison RS. Johnson MD, et al. J Biol Chem. 2002 Jun 21;277(25):23000-7. doi: 10.1074/jbc.M201907200. Epub 2002 Apr 9. J Biol Chem. 2002. PMID: 11943780
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