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A small-molecule agonist of the Wnt signaling pathway.
Liu J, Wu X, Mitchell B, Kintner C, Ding S, Schultz PG. Liu J, et al. Among authors: wu x. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90. doi: 10.1002/anie.200462552. Angew Chem Int Ed Engl. 2005. PMID: 15724259 No abstract available.
A small-molecule antagonist of the hedgehog signaling pathway.
Lee J, Wu X, Pasca di Magliano M, Peters EC, Wang Y, Hong J, Hebrok M, Ding S, Cho CY, Schultz PG. Lee J, et al. Among authors: wu x. Chembiochem. 2007 Nov 5;8(16):1916-9. doi: 10.1002/cbic.200700403. Chembiochem. 2007. PMID: 17886323 No abstract available.
A small molecule primes embryonic stem cells for differentiation.
Zhu S, Wurdak H, Wang J, Lyssiotis CA, Peters EC, Cho CY, Wu X, Schultz PG. Zhu S, et al. Among authors: wu x. Cell Stem Cell. 2009 May 8;4(5):416-26. doi: 10.1016/j.stem.2009.04.001. Cell Stem Cell. 2009. PMID: 19427291 Free article.
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.
Liu J, Pan S, Hsieh MH, Ng N, Sun F, Wang T, Kasibhatla S, Schuller AG, Li AG, Cheng D, Li J, Tompkins C, Pferdekamper A, Steffy A, Cheng J, Kowal C, Phung V, Guo G, Wang Y, Graham MP, Flynn S, Brenner JC, Li C, Villarroel MC, Schultz PG, Wu X, McNamara P, Sellers WR, Petruzzelli L, Boral AL, Seidel HM, McLaughlin ME, Che J, Carey TE, Vanasse G, Harris JL. Liu J, et al. Among authors: wu x. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9. doi: 10.1073/pnas.1314239110. Epub 2013 Nov 25. Proc Natl Acad Sci U S A. 2013. PMID: 24277854 Free PMC article.
Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma.
Chen EY, DeRan MT, Ignatius MS, Grandinetti KB, Clagg R, McCarthy KM, Lobbardi RM, Brockmann J, Keller C, Wu X, Langenau DM. Chen EY, et al. Among authors: wu x. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5349-54. doi: 10.1073/pnas.1317731111. Epub 2014 Mar 24. Proc Natl Acad Sci U S A. 2014. PMID: 24706870 Free PMC article.
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