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2006 1
2023 12
2024 325

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326 results

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Page 1
DDR1-targeted therapies: current limitations and future potential.
Wu D, Ding Z, Lu T, Chen Y, Zhang F, Lu S. Wu D, et al. Drug Discov Today. 2024 May;29(5):103975. doi: 10.1016/j.drudis.2024.103975. Epub 2024 Apr 4. Drug Discov Today. 2024. PMID: 38580164 Review.
The complex interplay between DDR1 and the extracellular matrix (ECM) necessitates additional validation, given that DDR1 might exhibit complex and synergistic interactions with other signaling molecules during ECM regulation. The mechanisms involved in DDR1 regulation in …
The complex interplay between DDR1 and the extracellular matrix (ECM) necessitates additional validation, given that DDR1 might exhibit comp …
Recycling and Degradation of Polyamides.
Zheng L, Wang M, Li Y, Xiong Y, Wu C. Zheng L, et al. Molecules. 2024 Apr 11;29(8):1742. doi: 10.3390/molecules29081742. Molecules. 2024. PMID: 38675560 Free PMC article. Review.
Small-Molecule Inhibitors and Biologics for Palmoplantar Psoriasis and Palmoplantar Pustulosis: A Systematic Review and Network Meta-Analysis.
Huang IH, Wu PC, Chiu HY, Huang YH. Huang IH, et al. Am J Clin Dermatol. 2024 May;25(3):347-358. doi: 10.1007/s40257-024-00849-0. Epub 2024 Mar 4. Am J Clin Dermatol. 2024. PMID: 38438782
BACKGROUND: The comparative efficacy of biologics and small-molecule inhibitors in treating palmoplantar psoriasis (PP) and palmoplantar pustulosis (PPP) remains uncertain. ...CONCLUSION: Among all available biologics and small-molecule inhibitors, secukinumab 300 m …
BACKGROUND: The comparative efficacy of biologics and small-molecule inhibitors in treating palmoplantar psoriasis (PP) and palmoplan …
Safety, pharmacokinetics and pharmacodynamics of HRS-7535, a novel oral small molecule glucagon-like peptide-1 receptor agonist, in healthy participants: A phase 1, randomized, double-blind, placebo-controlled, single- and multiple-ascending dose, and food effect trial.
Wu J, Zhou R, Zhang Q, Zhang Q, Qin H, Ye Z, Xu Y, Feng S, Shu C, Shen Y, Fan Y, Wang Q, Du Y, Hu W. Wu J, et al. Diabetes Obes Metab. 2024 Mar;26(3):901-910. doi: 10.1111/dom.15383. Epub 2023 Dec 15. Diabetes Obes Metab. 2024. PMID: 38100147 Clinical Trial.
PKs were approximately dose-proportional. On day 29 in the MAD part, the mean (percentage) reduction in body weight from baseline was 4.38 kg (6.63%) for participants who received HRS-7535, compared with 0.8 kg (1.18%) for those participants who received a placebo. ...
PKs were approximately dose-proportional. On day 29 in the MAD part, the mean (percentage) reduction in body weight from baseline was …
Targeting Moonlighting Enzymes in Cancer.
Lin C, Yu M, Wu X, Wang H, Wei M, Zhang L. Lin C, et al. Molecules. 2024 Apr 1;29(7):1573. doi: 10.3390/molecules29071573. Molecules. 2024. PMID: 38611852 Free PMC article. Review.
Investigation of GPR143 as a promising novel marker for the progression of skin cutaneous melanoma through bioinformatic analyses and cell experiments.
Bai R, Yin P, Xing Z, Wu S, Zhang W, Ma X, Gan X, Liang Y, Zang Q, Lei H, Wei Y, Zhang C, Dai B, Zheng Y. Bai R, et al. Apoptosis. 2024 Apr;29(3-4):372-392. doi: 10.1007/s10495-023-01913-6. Epub 2023 Nov 9. Apoptosis. 2024. PMID: 37945816
The Connectivity Map database was used to discover potentially effective therapeutic molecules against SKCM. Finally, we conducted cell experiments to investigate the potential role of GPR143 in SKCM. ...
The Connectivity Map database was used to discover potentially effective therapeutic molecules against SKCM. Finally, we conducted ce …
Wearable electrochemical sensors for plant small-molecule detection.
Zhou S, Zhou J, Pan Y, Wu Q, Ping J. Zhou S, et al. Trends Plant Sci. 2024 Feb;29(2):219-231. doi: 10.1016/j.tplants.2023.11.013. Epub 2023 Dec 8. Trends Plant Sci. 2024. PMID: 38071111 Review.
Small molecules in plants - such as metabolites, phytohormones, reactive oxygen species (ROS), and inorganic ions - participate in the processes of plant growth and development, physiological metabolism, and stress response. ...In this review we explore the applications of …
Small molecules in plants - such as metabolites, phytohormones, reactive oxygen species (ROS), and inorganic ions - participate in th …
Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancer.
Liu S, Tao Y, Wu S, Lin J, Fu S, Lu J, Zhang J, Fu B, Zhang E, Xu J, Wang J, Li L, Zhang L, Wang Z. Liu S, et al. Chin Med. 2024 Jan 9;19(1):7. doi: 10.1186/s13020-024-00881-6. Chin Med. 2024. PMID: 38195593 Free PMC article.
Nevertheless, the precise mechanism underlying the regulation of ferroptosis by S.C remains poorly understood. METHODS: A small molecule library was constructed based on FDA and CFDA approved small molecular drugs. CCK-8 assay was applied to evaluate the effects of the sma …
Nevertheless, the precise mechanism underlying the regulation of ferroptosis by S.C remains poorly understood. METHODS: A small molecule …
Research Progress on Benzimidazole Fungicides: A Review.
Bai S, Zhang M, Tang S, Li M, Wu R, Wan S, Chen L, Wei X, Li F. Bai S, et al. Molecules. 2024 Mar 8;29(6):1218. doi: 10.3390/molecules29061218. Molecules. 2024. PMID: 38542855 Free PMC article. Review.
Huzhangqingmaiyin protected vascular endothelial cells against cerebral small vessel disease through inhibiting inflammation.
Li MT, Ke J, Guo SF, Shan LL, Gong JH, Qiao TC, Tian HY, Wu Y, Peng ZY, Zeng XQ, Han Y. Li MT, et al. J Ethnopharmacol. 2024 Jan 10;318(Pt A):116905. doi: 10.1016/j.jep.2023.116905. Epub 2023 Jul 11. J Ethnopharmacol. 2024. PMID: 37442491 Free article.
RESULTS: HZQMY at 0.5-2 mug/mL concentration range could promote cell proliferation, cell migration, angiogenesis, reduce mitochondrial membrane potential damage as well as inhibit apoptosis. Besides that, 29 active compounds were detected from HZQMY, including key compone …
RESULTS: HZQMY at 0.5-2 mug/mL concentration range could promote cell proliferation, cell migration, angiogenesis, reduce mitochondrial memb …
326 results