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TOR signaling in growth and metabolism.
Wullschleger S, Loewith R, Hall MN. Wullschleger S, et al. Cell. 2006 Feb 10;124(3):471-84. doi: 10.1016/j.cell.2006.01.016. Cell. 2006. PMID: 16469695 Review.
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN. Loewith R, et al. Among authors: wullschleger s. Mol Cell. 2002 Sep;10(3):457-68. doi: 10.1016/s1097-2765(02)00636-6. Mol Cell. 2002. PMID: 12408816
Molecular organization of target of rapamycin complex 2.
Wullschleger S, Loewith R, Oppliger W, Hall MN. Wullschleger S, et al. J Biol Chem. 2005 Sep 2;280(35):30697-704. doi: 10.1074/jbc.M505553200. Epub 2005 Jul 7. J Biol Chem. 2005. PMID: 16002396
Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation.
Göransson O, Deak M, Wullschleger S, Morrice NA, Prescott AR, Alessi DR. Göransson O, et al. Among authors: wullschleger s. J Cell Sci. 2006 Oct 1;119(Pt 19):4059-70. doi: 10.1242/jcs.03097. Epub 2006 Sep 12. J Cell Sci. 2006. PMID: 16968750
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.
Kamada Y, Fujioka Y, Suzuki NN, Inagaki F, Wullschleger S, Loewith R, Hall MN, Ohsumi Y. Kamada Y, et al. Among authors: wullschleger s. Mol Cell Biol. 2005 Aug;25(16):7239-48. doi: 10.1128/MCB.25.16.7239-7248.2005. Mol Cell Biol. 2005. PMID: 16055732 Free PMC article.
Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
Pearce LR, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR. Pearce LR, et al. Among authors: wullschleger s. Biochem J. 2007 Aug 1;405(3):513-22. doi: 10.1042/BJ20070540. Biochem J. 2007. PMID: 17461779 Free PMC article.
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice.
Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, McBurnie W, Fleming S, Alessi DR. Huang X, et al. Among authors: wullschleger s. Biochem J. 2008 Jun 1;412(2):211-21. doi: 10.1042/BJ20080557. Biochem J. 2008. PMID: 18387000
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR. Bayascas JR, et al. Among authors: wullschleger s. Mol Cell Biol. 2008 May;28(10):3258-72. doi: 10.1128/MCB.02032-07. Epub 2008 Mar 17. Mol Cell Biol. 2008. PMID: 18347057 Free PMC article.
Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice.
García-Martínez JM, Wullschleger S, Preston G, Guichard S, Fleming S, Alessi DR, Duce SL. García-Martínez JM, et al. Among authors: wullschleger s. Br J Cancer. 2011 Mar 29;104(7):1116-25. doi: 10.1038/bjc.2011.83. Epub 2011 Mar 15. Br J Cancer. 2011. PMID: 21407213 Free PMC article.
Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.
Pearce LR, Sommer EM, Sakamoto K, Wullschleger S, Alessi DR. Pearce LR, et al. Among authors: wullschleger s. Biochem J. 2011 May 15;436(1):169-79. doi: 10.1042/BJ20102103. Biochem J. 2011. PMID: 21413931
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