Abstract
Feeding choline, a precursor of the neurotransmitter acetylcholine, has been shown experimentally to increase brain acetylcholine release and enhance cholinergic function A subsequent trial of oral choline ameliorated symptoms in patients with tardive dyskinesia, which has been linked to cholinergic dysfunction. The findings suggest a role for dietary precursors in treating diseases associated with neurotransmitter abnormality.
MeSH terms
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Acetylcholine / biosynthesis
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Acetylcholine / metabolism*
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Administration, Oral
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Brain / metabolism*
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Choline / administration & dosage*
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Choline / metabolism
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Choline / therapeutic use
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Clinical Trials as Topic
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Diet
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Dyskinesia, Drug-Induced / drug therapy*
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Humans
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Huntington Disease / drug therapy
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Physostigmine / administration & dosage
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Serotonin / metabolism
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Tryptophan / administration & dosage
Substances
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Serotonin
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Tryptophan
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Physostigmine
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Choline
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Acetylcholine