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A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation.
Wutz A, Jaenisch R. Wutz A, et al. Mol Cell. 2000 Apr;5(4):695-705. doi: 10.1016/s1097-2765(00)80248-8. Mol Cell. 2000. PMID: 10882105
To study the initiation of X inactivation, we have generated a full-length mouse Xist cDNA transgene and an inducible expression system facilitating controlled Xist expression in ES cells and differentiated cultures. ...Xist had to be activated within 48 hr of differentiat …
To study the initiation of X inactivation, we have generated a full-length mouse Xist cDNA transgene and an inducible expression syst …
Insights into the Establishment of Chromatin States in Pluripotent Cells from Studies of X Inactivation.
Postlmayr A, Wutz A. Postlmayr A, et al. J Mol Biol. 2017 May 19;429(10):1521-1531. doi: 10.1016/j.jmb.2017.03.013. Epub 2017 Mar 16. J Mol Biol. 2017. PMID: 28315662 Review.
During cell differentiation, transcription factors, cell signaling pathways, and chromatin-associated protein complexes cooperate in regulating the expression of a large number of genes. Here, we review the present understanding of the establishment of chromatin states by …
During cell differentiation, transcription factors, cell signaling pathways, and chromatin-associated protein complexes cooperate in regulat …
Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells.
Monfort A, Di Minin G, Postlmayr A, Freimann R, Arieti F, Thore S, Wutz A. Monfort A, et al. Cell Rep. 2015 Jul 28;12(4):554-61. doi: 10.1016/j.celrep.2015.06.067. Epub 2015 Jul 16. Cell Rep. 2015. PMID: 26190100 Free PMC article.
Here, we report a genetic screen for silencing factors in X chromosome inactivation using haploid mouse embryonic stem cells (ESCs) that carry an engineered selectable reporter system. ...
Here, we report a genetic screen for silencing factors in X chromosome inactivation using haploid mouse embryonic stem cells (ESCs) t …
Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome.
da Rocha ST, Boeva V, Escamilla-Del-Arenal M, Ancelin K, Granier C, Matias NR, Sanulli S, Chow J, Schulz E, Picard C, Kaneko S, Helin K, Reinberg D, Stewart AF, Wutz A, Margueron R, Heard E. da Rocha ST, et al. Mol Cell. 2014 Jan 23;53(2):301-16. doi: 10.1016/j.molcel.2014.01.002. Mol Cell. 2014. PMID: 24462204
Xist-induced Jarid2 recruitment occurs chromosome-wide independently of a functional PRC2 complex, unlike at other parts of the genome, such as CG-rich regions, where Jarid2 and PRC2 binding are interdependent. ...
Xist-induced Jarid2 recruitment occurs chromosome-wide independently of a functional PRC2 complex, unlike at other parts of the genom …
LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation.
Chow JC, Ciaudo C, Fazzari MJ, Mise N, Servant N, Glass JL, Attreed M, Avner P, Wutz A, Barillot E, Greally JM, Voinnet O, Heard E. Chow JC, et al. Cell. 2010 Jun 11;141(6):956-69. doi: 10.1016/j.cell.2010.04.042. Cell. 2010. PMID: 20550932
Little is known about how XCI spreads across the chromosome, although LINE-1 elements have been proposed to play a role. Here we show that LINEs participate in creating a silent nuclear compartment into which genes become recruited. A subset of young LINE-1 e …
Little is known about how XCI spreads across the chromosome, although LINE-1 elements have been proposed to play a role. Here we show …
A system for imaging the regulatory noncoding Xist RNA in living mouse embryonic stem cells.
Ng K, Daigle N, Bancaud A, Ohhata T, Humphreys P, Walker R, Ellenberg J, Wutz A. Ng K, et al. Mol Biol Cell. 2011 Jul 15;22(14):2634-45. doi: 10.1091/mbc.E11-02-0146. Epub 2011 May 25. Mol Biol Cell. 2011. PMID: 21613549 Free PMC article.
To understand localization of Xist over one X chromosome we aimed to develop a system for investigating Xist in living cells. ...Imaging of Xist during an entire cell cycle shows that Xist spreads from a single point to a steady state when the chromosome is c …
To understand localization of Xist over one X chromosome we aimed to develop a system for investigating Xist in living cells. ...Imag …
ConteXt of change--X inactivation and disease.
Agrelo R, Wutz A. Agrelo R, et al. EMBO Mol Med. 2010 Jan;2(1):6-15. doi: 10.1002/emmm.200900053. EMBO Mol Med. 2010. PMID: 20043281 Free PMC article.
Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells.
Leeb M, Wutz A. Leeb M, et al. J Cell Biol. 2007 Jul 16;178(2):219-29. doi: 10.1083/jcb.200612127. Epub 2007 Jul 9. J Cell Biol. 2007. PMID: 17620408 Free PMC article.
Ring1B protein contains a RING finger domain and functions as an E3 ubiquitin ligase that is crucial for the monoubiquitination of histone H2A (H2AK119ub1). ...Despite a crucial function of Ring1B in establishing the chromosome-wide ubiquitination of histone H2A lys …
Ring1B protein contains a RING finger domain and functions as an E3 ubiquitin ligase that is crucial for the monoubiquitination of hi …
Reprogramming of Xist against the pluripotent state in fusion hybrids.
Do JT, Han DW, Gentile L, Sobek-Klocke I, Wutz A, Schöler HR. Do JT, et al. J Cell Sci. 2009 Nov 15;122(Pt 22):4122-9. doi: 10.1242/jcs.056119. Epub 2009 Oct 20. J Cell Sci. 2009. PMID: 19843582
Because the ;memory' of somatic cells seems to be erased during fusion-induced reprogramming, genetic reprogramming is thought to be a largely unidirectional process. Here we show that fusion-induced reprogramming, which brings about the formation of pluripotent hybrids, d …
Because the ;memory' of somatic cells seems to be erased during fusion-induced reprogramming, genetic reprogramming is thought to be a
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