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Year Number of Results
2003 1
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2008 2
2009 1
2012 1
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2015 1
2016 3
2017 2
2018 2
2019 2
2020 0
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Page 1
Hepatic p63 regulates steatosis via IKKβ/ER stress.
Porteiro B, Fondevila MF, Delgado TC, Iglesias C, Imbernon M, Iruzubieta P, Crespo J, Zabala-Letona A, Fernø J, González-Terán B, Matesanz N, Hernández-Cosido L, Marcos M, Tovar S, Vidal A, Sánchez-Ceinos J, Malagon MM, Pombo C, Zalvide J, Carracedo A, Buque X, Dieguez C, Sabio G, López M, Aspichueta P, Martínez-Chantar ML, Nogueiras R. Porteiro B, et al. Nat Commun. 2017 May 8;8:15111. doi: 10.1038/ncomms15111. Nat Commun. 2017. PMID: 28480888 Free PMC article.
Hepatic overexpression of N-terminal transactivation domain TAp63 induces liver steatosis through IKKβ activation and the induction of ER stress, the inhibition of which rescues the liver functions. Expression of TAp63, IKKβ and XBP1s is also increased in livers
Hepatic overexpression of N-terminal transactivation domain TAp63 induces liver steatosis through IKKβ activation and the induction o …
Epithelial Xbp1 is required for cellular proliferation and differentiation during mammary gland development.
Hasegawa D, Calvo V, Avivar-Valderas A, Lade A, Chou HI, Lee YA, Farias EF, Aguirre-Ghiso JA, Friedman SL. Hasegawa D, et al. Mol Cell Biol. 2015 May;35(9):1543-56. doi: 10.1128/MCB.00136-15. Epub 2015 Feb 23. Mol Cell Biol. 2015. PMID: 25713103 Free PMC article.
However, the direct function of Xbp1 in epithelial cells during mammary gland development is unknown. Here we report that the loss of Xbp1 in the mammary epithelium through targeted deletion leads to poor branching morphogenesis, impaired terminal end bud formation, …
However, the direct function of Xbp1 in epithelial cells during mammary gland development is unknown. Here we report that the loss of …
Sexual dimorphism of liver endoplasmic reticulum stress susceptibility in prepubertal rats and the effect of sex steroid supplementation.
Rossetti CL, de Oliveira Costa HM, Barthem CS, da Silva MH, de Carvalho DP, da-Silva WS. Rossetti CL, et al. Exp Physiol. 2019 May;104(5):677-690. doi: 10.1113/EP087518. Epub 2019 Mar 20. Exp Physiol. 2019. PMID: 30821070
The transition from prepubertal to the adult age is associated with an increase in the unfolded protein response markers in the liver of male rats, which is probably due to an increase in serum testosterone levels. ...In the first experimental model, male and female …
The transition from prepubertal to the adult age is associated with an increase in the unfolded protein response markers in the li
Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium.
Moore BD, Khurana SS, Huh WJ, Mills JC. Moore BD, et al. Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G267-75. doi: 10.1152/ajpgi.00195.2016. Epub 2016 Jun 23. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 27340127 Free PMC article.
Here we sought to identify transcriptional regulators upstream of X-box binding protein 1 (XBP1) and MIST1. We used immunohistochemistry to characterize Hnf4α(flox/flox) adult mouse stomachs after tamoxifen-induced deletion of Hnf4α We used qRT-PCR, Western blotting …
Here we sought to identify transcriptional regulators upstream of X-box binding protein 1 (XBP1) and MIST1. We used immunohistochemis …
The role of XBP1s in the metastasis and prognosis of hepatocellular carcinoma.
Wu S, Du R, Gao C, Kang J, Wen J, Sun T. Wu S, et al. Biochem Biophys Res Commun. 2018 Jun 7;500(3):530-537. doi: 10.1016/j.bbrc.2018.04.033. Epub 2018 Apr 25. Biochem Biophys Res Commun. 2018. PMID: 29627568
Syzygium cumini Leaf Extract Reverts Hypertriglyceridemia via Downregulation of the Hepatic XBP-1s/PDI/MTP Axis in Monosodium L-Glutamate-Induced Obese Rats.
França LM, Coêlho CFF, Freitas LNC, Souza ILS, Chagas VT, Debbas V, de Lima TM, de Souza HP, Laurindo FRM, Paes AMA. França LM, et al. Oxid Med Cell Longev. 2019 Mar 21;2019:9417498. doi: 10.1155/2019/9417498. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31015892 Free PMC article.
Another set of adult nonobese Wistar rats was used for the assessment of HESc acute effects on Triton WR1339-induced hypertriglyceridemia. ...Our data support the downregulation of the XBP-1s/PDI/MTP axis in the liver of MSG-obese rats as a novel feasible mechanism …
Another set of adult nonobese Wistar rats was used for the assessment of HESc acute effects on Triton WR1339-induced hypertriglycerid …
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease.
Puri P, Mirshahi F, Cheung O, Natarajan R, Maher JW, Kellum JM, Sanyal AJ. Puri P, et al. Gastroenterology. 2008 Feb;134(2):568-76. doi: 10.1053/j.gastro.2007.10.039. Epub 2007 Oct 26. Gastroenterology. 2008. PMID: 18082745
The aims were to (1) evaluate the activity of UPR in NAFL and NASH and (2) correlate expression of UPR pathways with liver histology. ...Liver histology was scored using the NASH clinical research network criteria. RESULTS: Compared with subjects with the metabolic …
The aims were to (1) evaluate the activity of UPR in NAFL and NASH and (2) correlate expression of UPR pathways with liver histology. …
The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life.
Deodati A, Argemí J, Germani D, Puglianiello A, Alisi A, De Stefanis C, Ferrero R, Nobili V, Aragón T, Cianfarani S. Deodati A, et al. PLoS One. 2018 Jun 13;13(6):e0198490. doi: 10.1371/journal.pone.0198490. eCollection 2018. PLoS One. 2018. PMID: 29897997 Free PMC article.
Early life events are associated with the susceptibility to chronic diseases in adult life. Perturbations of endoplasmic reticulum (ER) homeostasis activate the unfolded protein response (UPR), which contributes to the development of metabolic alterations. ...A significant …
Early life events are associated with the susceptibility to chronic diseases in adult life. Perturbations of endoplasmic reticulum (E …
From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis.
Glimcher LH, Lee AH. Glimcher LH, et al. Ann N Y Acad Sci. 2009 Sep;1173 Suppl 1(Suppl 1):E2-9. doi: 10.1111/j.1749-6632.2009.04956.x. Ann N Y Acad Sci. 2009. PMID: 19751410 Free PMC article. Review.
We have recently discovered that the transcription factor XBP1, best known as a key regulator of the unfolded protein response (UPR), is required for de novo fatty acid synthesis in the liver, a function unrelated to its role in the UPR.(1) XBP1 protein expre …
We have recently discovered that the transcription factor XBP1, best known as a key regulator of the unfolded protein response (UPR), …
Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines.
Das SK, Chu WS, Mondal AK, Sharma NK, Kern PA, Rasouli N, Elbein SC. Das SK, et al. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E393-400. doi: 10.1152/ajpendo.90355.2008. Epub 2008 Jun 10. Am J Physiol Endocrinol Metab. 2008. PMID: 18544642 Free PMC article. Clinical Trial.
We also experimentally induced endoplasmic reticulum stress using palmitate, tunicamycin, and thapsigargin in the human HepG2 liver cell line with or without pioglitazone pretreatment. ...In vitro, palmitate, thapsigargin, and tunicamycin but not oleate induced endoplasmic …
We also experimentally induced endoplasmic reticulum stress using palmitate, tunicamycin, and thapsigargin in the human HepG2 liver c …
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