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Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α.
Duwaerts CC, Siao K, Soon RK Jr, Her C, Iwawaki T, Kohno K, Mattis AN, Maher JJ. Duwaerts CC, et al. Cell Death Differ. 2021 May;28(5):1455-1465. doi: 10.1038/s41418-020-00671-1. Epub 2020 Nov 20. Cell Death Differ. 2021. PMID: 33219328 Free PMC article.
The objective of the current study was to investigate the effects of XBP1 deletion in adult mouse liver and determine to what extent they are direct or indirect. XBP1 was deleted from hepatocytes in adult Xbp1(fl/fl) mice using AAV8-Trans …
The objective of the current study was to investigate the effects of XBP1 deletion in adult mouse liver and determine t …
Sexual dimorphism of liver endoplasmic reticulum stress susceptibility in prepubertal rats and the effect of sex steroid supplementation.
Rossetti CL, de Oliveira Costa HM, Barthem CS, da Silva MH, de Carvalho DP, da-Silva WS. Rossetti CL, et al. Exp Physiol. 2019 May;104(5):677-690. doi: 10.1113/EP087518. Epub 2019 Mar 20. Exp Physiol. 2019. PMID: 30821070 Free article.
What is the main finding and its importance? The transition from prepubertal to the adult age is associated with an increase in the unfolded protein response markers in the liver of male rats, which is probably due to an increase in serum testosterone levels. ...In …
What is the main finding and its importance? The transition from prepubertal to the adult age is associated with an increase in the u …
Epithelial Xbp1 is required for cellular proliferation and differentiation during mammary gland development.
Hasegawa D, Calvo V, Avivar-Valderas A, Lade A, Chou HI, Lee YA, Farias EF, Aguirre-Ghiso JA, Friedman SL. Hasegawa D, et al. Mol Cell Biol. 2015 May;35(9):1543-56. doi: 10.1128/MCB.00136-15. Epub 2015 Feb 23. Mol Cell Biol. 2015. PMID: 25713103 Free PMC article.
However, the direct function of Xbp1 in epithelial cells during mammary gland development is unknown. Here we report that the loss of Xbp1 in the mammary epithelium through targeted deletion leads to poor branching morphogenesis, impaired terminal end bud formation, …
However, the direct function of Xbp1 in epithelial cells during mammary gland development is unknown. Here we report that the loss of …
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease.
Puri P, Mirshahi F, Cheung O, Natarajan R, Maher JW, Kellum JM, Sanyal AJ. Puri P, et al. Gastroenterology. 2008 Feb;134(2):568-76. doi: 10.1053/j.gastro.2007.10.039. Epub 2007 Oct 26. Gastroenterology. 2008. PMID: 18082745
BACKGROUND & AIMS: Nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) are associated with known triggers of the unfolded protein response (UPR). ...Apoptosis was assessed by TUNEL assay. Liver histology was scored using the NASH clinical res …
BACKGROUND & AIMS: Nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) are associated with known triggers of …
Hepatic p63 regulates steatosis via IKKβ/ER stress.
Porteiro B, Fondevila MF, Delgado TC, Iglesias C, Imbernon M, Iruzubieta P, Crespo J, Zabala-Letona A, Fernø J, González-Terán B, Matesanz N, Hernández-Cosido L, Marcos M, Tovar S, Vidal A, Sánchez-Ceinos J, Malagon MM, Pombo C, Zalvide J, Carracedo A, Buque X, Dieguez C, Sabio G, López M, Aspichueta P, Martínez-Chantar ML, Nogueiras R. Porteiro B, et al. Nat Commun. 2017 May 8;8:15111. doi: 10.1038/ncomms15111. Nat Commun. 2017. PMID: 28480888 Free PMC article.
Hepatic overexpression of N-terminal transactivation domain TAp63 induces liver steatosis through IKKbeta activation and the induction of ER stress, the inhibition of which rescues the liver functions. ...Our findings indicate an unexpected role of the p63/IKKbeta/E …
Hepatic overexpression of N-terminal transactivation domain TAp63 induces liver steatosis through IKKbeta activation and the inductio …
From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis.
Glimcher LH, Lee AH. Glimcher LH, et al. Ann N Y Acad Sci. 2009 Sep;1173 Suppl 1(Suppl 1):E2-9. doi: 10.1111/j.1749-6632.2009.04956.x. Ann N Y Acad Sci. 2009. PMID: 19751410 Free PMC article. Review.
We have recently discovered that the transcription factor XBP1, best known as a key regulator of the unfolded protein response (UPR), is required for de novo fatty acid synthesis in the liver, a function unrelated to its role in the UPR.(1) XBP1 protein expre …
We have recently discovered that the transcription factor XBP1, best known as a key regulator of the unfolded protein response (UPR), …
Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium.
Moore BD, Khurana SS, Huh WJ, Mills JC. Moore BD, et al. Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G267-75. doi: 10.1152/ajpgi.00195.2016. Epub 2016 Jun 23. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 27340127 Free PMC article.
Here we sought to identify transcriptional regulators upstream of X-box binding protein 1 (XBP1) and MIST1. We used immunohistochemistry to characterize Hnf4alpha(flox/flox) adult mouse stomachs after tamoxifen-induced deletion of Hnf4alpha We used qRT-PCR, Western …
Here we sought to identify transcriptional regulators upstream of X-box binding protein 1 (XBP1) and MIST1. We used immunohistochemis …
Hepatic X-Box Binding Protein 1 and Unfolded Protein Response Is Impaired in Weanling Mice With Resultant Hepatic Injury.
Kriegermeier A, Hyon A, Sommars M, Hubchak S, LeCuyer B, Liu X, Barish G, Green RM. Kriegermeier A, et al. Hepatology. 2021 Dec;74(6):3362-3375. doi: 10.1002/hep.32031. Epub 2021 Sep 9. Hepatology. 2021. PMID: 34170527
When ER stress is unresolved, the UPR can trigger apoptosis. Pathways within the UPR influence bile acid metabolism in adult animal models and adult human liver diseases, however, the UPR has not been studied in young animal models or pediatric liver d …
When ER stress is unresolved, the UPR can trigger apoptosis. Pathways within the UPR influence bile acid metabolism in adult animal m …
Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines.
Das SK, Chu WS, Mondal AK, Sharma NK, Kern PA, Rasouli N, Elbein SC. Das SK, et al. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E393-400. doi: 10.1152/ajpendo.90355.2008. Epub 2008 Jun 10. Am J Physiol Endocrinol Metab. 2008. PMID: 18544642 Free PMC article. Clinical Trial.
We also experimentally induced endoplasmic reticulum stress using palmitate, tunicamycin, and thapsigargin in the human HepG2 liver cell line with or without pioglitazone pretreatment. We quantified endoplasmic reticulum stress response by measuring both gene expression an …
We also experimentally induced endoplasmic reticulum stress using palmitate, tunicamycin, and thapsigargin in the human HepG2 liver c …
The Genomics of Elevated ALT and Adducts in Therapeutic Acetaminophen Treatment: a Pilot Study.
Monte AA, Sonn B, Saben J, Rumack BH, Reynolds KM, Dart RC, Heard KJ. Monte AA, et al. J Med Toxicol. 2021 Apr;17(2):160-167. doi: 10.1007/s13181-020-00815-2. Epub 2020 Oct 13. J Med Toxicol. 2021. PMID: 33051802 Free PMC article.
The etiology of this liver injury or adaption is unclear. Our objective was to identify new pharmacogenomic variants associated with elevated ALT or elevated protein adduct concentrations in patients receiving therapeutic acetaminophen. ...CONCLUSIONS: While underpowered, …
The etiology of this liver injury or adaption is unclear. Our objective was to identify new pharmacogenomic variants associated with …
23 results