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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1907 1
1910 1
1913 1
1924 3
1925 3
1926 4
1927 1
1928 1
1930 1
1932 1
1934 3
1935 2
1936 1
1938 4
1939 4
1942 1
1943 2
1945 22
1946 65
1947 64
1948 63
1949 79
1950 127
1951 153
1952 158
1953 238
1954 199
1955 214
1956 213
1957 246
1958 202
1959 221
1960 191
1961 200
1962 287
1963 434
1964 681
1965 565
1966 594
1967 758
1968 979
1969 1068
1970 1174
1971 1202
1972 1345
1973 1480
1974 1603
1975 1510
1976 1420
1977 1436
1978 1373
1979 1498
1980 1569
1981 1581
1982 1631
1983 1724
1984 1987
1985 2001
1986 2050
1987 1994
1988 1973
1989 2137
1990 2116
1991 2136
1992 1956
1993 2111
1994 2105
1995 1913
1996 1905
1997 1887
1998 1862
1999 1783
2000 1943
2001 1815
2002 1751
2003 1719
2004 1762
2005 1814
2006 2014
2007 1929
2008 2064
2009 1968
2010 2042
2011 2106
2012 2230
2013 2223
2014 2421
2015 2398
2016 2373
2017 2351
2018 2475
2019 2372
2020 2467
2021 2343
2022 2634
2023 2424
2024 835

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106,621 results

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Page 1
Inhibition of Xanthine Oxidase-Catalyzed Xanthine and 6-Mercaptopurine Oxidation by Flavonoid Aglycones and Some of Their Conjugates.
Mohos V, Fliszár-Nyúl E, Poór M. Mohos V, et al. Int J Mol Sci. 2020 May 5;21(9):3256. doi: 10.3390/ijms21093256. Int J Mol Sci. 2020. PMID: 32380641 Free PMC article.
It is well-known that some flavonoid aglycones are potent inhibitors of the xanthine oxidase (XO)-catalyzed uric acid formation in vitro. However, the effects of conjugated flavonoid metabolites are poorly characterized. ...Kaempferol, fisetin, geraldol, luteolin, diosmeti …
It is well-known that some flavonoid aglycones are potent inhibitors of the xanthine oxidase (XO)-catalyzed uric acid formation in vi …
Metal complexes of xanthine and its derivatives: Synthesis and biological activity.
Dar MO, Mir RH, Mohiuddin R, Masoodi MH, Sofi FA. Dar MO, et al. J Inorg Biochem. 2023 Sep;246:112290. doi: 10.1016/j.jinorgbio.2023.112290. Epub 2023 Jun 10. J Inorg Biochem. 2023. PMID: 37327591 Review.
Xanthine and its derivatives are considered an important class of N-heterocyclic purine compounds that have gained significant importance in medicinal chemistry. ...The metal complexes of xanthine and its derivatives shall pave the way for the rational design and de …
Xanthine and its derivatives are considered an important class of N-heterocyclic purine compounds that have gained significant import …
Biosensing methods for xanthine determination: a review.
Pundir CS, Devi R. Pundir CS, et al. Enzyme Microb Technol. 2014 Apr 10;57:55-62. doi: 10.1016/j.enzmictec.2013.12.006. Epub 2014 Jan 30. Enzyme Microb Technol. 2014. PMID: 24629268 Review.
Xanthine (3,7-dihydro-purine-2,6-dione) is generated from guanine by guanine deaminase and hypoxanthine by xanthine oxidase (XOD). ...The future perspectives for improvement of present xanthine biosensors are also discussed....
Xanthine (3,7-dihydro-purine-2,6-dione) is generated from guanine by guanine deaminase and hypoxanthine by xanthine oxidase (X …
Purine metabolites can indicate diabetes progression.
Varadaiah YGC, Sivanesan S, Nayak SB, Thirumalarao KR. Varadaiah YGC, et al. Arch Physiol Biochem. 2022 Feb;128(1):87-91. doi: 10.1080/13813455.2019.1663219. Epub 2019 Sep 13. Arch Physiol Biochem. 2022. PMID: 31517540
MATERIALS AND METHODS: Alloxan was administered to induce diabetes in rats. After 30 days, the levels of uric acid, inosine, xanthine, hypoxanthine and AMP were assessed in both plasma and liver tissues using HPLC technique. RESULTS: A significant increase in xanthine …
MATERIALS AND METHODS: Alloxan was administered to induce diabetes in rats. After 30 days, the levels of uric acid, inosine, xanthine …
Super-Robust Xanthine-Sodium Complexes on Au(111).
Chen C, Ding PC, Li Z, Shi GQ, Sun Y, Kantorovich LN, Besenbacher F, Yu M. Chen C, et al. Angew Chem Int Ed Engl. 2022 Apr 11;61(16):e202200064. doi: 10.1002/anie.202200064. Epub 2022 Feb 23. Angew Chem Int Ed Engl. 2022. PMID: 35133710
Nevertheless, the low desorption temperature from inorganic substrates and the fragileness of hydrogen-bonded nucleobases do not support the required thermal stability in such an environment. Herein, we report the super-robust complexes of xanthine, one of the precursors f …
Nevertheless, the low desorption temperature from inorganic substrates and the fragileness of hydrogen-bonded nucleobases do not support the …
[Oxypurine].
Kono N. Kono N. Nihon Rinsho. 1999 Aug;57 Suppl:555-7. Nihon Rinsho. 1999. PMID: 10503498 Review. Japanese. No abstract available.
Synthesis and evaluation of novel xanthine-acrylamides and xanthine-acrylates as insecticidal agents.
Zhang S, Liu H, Yang N, Xiong L, Wang B. Zhang S, et al. Pest Manag Sci. 2022 May;78(5):2086-2095. doi: 10.1002/ps.6834. Epub 2022 Mar 1. Pest Manag Sci. 2022. PMID: 35142104
BACKGROUND: The design and discovery of novel pesticidal agents according to bioactive natural products is an important aspect of agrochemical innovation. New xanthine derivatives derived from natural xanthine or methylxanthines are rich resources that possess great …
BACKGROUND: The design and discovery of novel pesticidal agents according to bioactive natural products is an important aspect of agrochemic …
Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis.
Schmidt HM, DeVallance ER, Lewis SE, Wood KC, Annarapu GK, Carreño M, Hahn SA, Seman M, Maxwell BA, Hileman EA, Xu JZ, Velayutham M, Geldenhuys WJ, Vitturi DA, Shiva S, Kelley EE, Straub AC. Schmidt HM, et al. Redox Biol. 2023 Jun;62:102636. doi: 10.1016/j.redox.2023.102636. Epub 2023 Feb 13. Redox Biol. 2023. PMID: 36906950 Free PMC article.
Xanthine oxidase (XO) catalyzes the catabolism of hypoxanthine to xanthine and xanthine to uric acid, generating oxidants as a byproduct. ...
Xanthine oxidase (XO) catalyzes the catabolism of hypoxanthine to xanthine and xanthine to uric acid, generating oxidan …
Xanthine urolithiasis: Inhibitors of xanthine crystallization.
Grases F, Costa-Bauza A, Roig J, Rodriguez A. Grases F, et al. PLoS One. 2018 Aug 29;13(8):e0198881. doi: 10.1371/journal.pone.0198881. eCollection 2018. PLoS One. 2018. PMID: 30157195 Free PMC article.
OBJECTIVE: To identify in vitro inhibitors of xanthine crystallization that have potential for inhibiting the formation of xanthine crystals in urine and preventing the development of the renal calculi in patients with xanthinuria. METHODS: The formation of xanth …
OBJECTIVE: To identify in vitro inhibitors of xanthine crystallization that have potential for inhibiting the formation of xanthin …
Caffeine analogs: biomedical impact.
Daly JW. Daly JW. Cell Mol Life Sci. 2007 Aug;64(16):2153-69. doi: 10.1007/s00018-007-7051-9. Cell Mol Life Sci. 2007. PMID: 17514358 Review.
Caffeine, widely consumed in beverages, and many xanthine analogs have had a major impact on biomedical research. Caffeine and various analogs, the latter designed to enhance potency and selectivity toward specific biological targets, have played key roles in defining the …
Caffeine, widely consumed in beverages, and many xanthine analogs have had a major impact on biomedical research. Caffeine and variou …
106,621 results
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