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468 results

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Page 1
Xanthohumol reduces inflammation and cell metabolism in HT29 primary colon cancer cells.
Torrens-Mas M, Alorda-Clara M, Martínez-Vigara M, Roca P, Sastre-Serra J, Oliver J, Pons DG. Torrens-Mas M, et al. Int J Food Sci Nutr. 2022 Jun;73(4):471-479. doi: 10.1080/09637486.2021.2012561. Epub 2021 Dec 8. Int J Food Sci Nutr. 2022. PMID: 34879764
Xanthohumol (XN) is a prenylated flavonoid known for its antioxidant and anti-inflammatory effects and has been studied as an anti-cancer agent. In this study, we aimed at analysing the effect of XN on a primary colorectal adenocarcinoma cell line, HT29, on cell viability, …
Xanthohumol (XN) is a prenylated flavonoid known for its antioxidant and anti-inflammatory effects and has been studied as an anti-ca …
Absorption, metabolism, and pharmacokinetic profile of xanthohumol in rats as determined via UPLC-MS/MS.
Bai HH, Xia TS, Jiang YP, Xu WM, Xu PC, Wang NN, Gou XJ, Xin HL. Bai HH, et al. Biopharm Drug Dispos. 2022 Feb;43(1):11-22. doi: 10.1002/bdd.2306. Epub 2021 Dec 27. Biopharm Drug Dispos. 2022. PMID: 34914109
However, the biological fate of xanthohumol in vivo remains unclear. The aim of this study was to investigate the absorption and metabolism of xanthohumol in rats through UPLC-MS/MS. ...Besides, isoxanthohumol was the major metabolites of xanthohumol. …
However, the biological fate of xanthohumol in vivo remains unclear. The aim of this study was to investigate the absorption and m …
Reductive Metabolism of Xanthohumol and 8-Prenylnaringenin by the Intestinal Bacterium Eubacterium ramulus.
Paraiso IL, Plagmann LS, Yang L, Zielke R, Gombart AF, Maier CS, Sikora AE, Blakemore PR, Stevens JF. Paraiso IL, et al. Mol Nutr Food Res. 2019 Jan;63(2):e1800923. doi: 10.1002/mnfr.201800923. Epub 2018 Dec 3. Mol Nutr Food Res. 2019. PMID: 30471194 Free PMC article.
This work aims to identify intestinal metabolites of xanthohumol (XN), a prenylated flavonoid found in hops (Humulus lupulus) and beer, as well as to identify pathways of metabolism of XN in the gut. ...CONCLUSION: Microbial metabolism is likely to affect bot …
This work aims to identify intestinal metabolites of xanthohumol (XN), a prenylated flavonoid found in hops (Humulus lupulus) and bee …
Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease.
Sahoo DK, Heilmann RM, Paital B, Patel A, Yadav VK, Wong D, Jergens AE. Sahoo DK, et al. Front Endocrinol (Lausanne). 2023 Aug 28;14:1217165. doi: 10.3389/fendo.2023.1217165. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37701897 Free PMC article. Review.
In this review, we discuss various polyphenolic substances (such as resveratrol, curcumin, quercetin, green tea flavonoids, caffeic acid phenethyl ester, luteolin, xanthohumol, genistein, alpinetin, proanthocyanidins, anthocyanins, silymarin), phenolic compounds including …
In this review, we discuss various polyphenolic substances (such as resveratrol, curcumin, quercetin, green tea flavonoids, caffeic acid phe …
Cell death regulation: A new way for natural products to treat osteoporosis.
Li Z, Li D, Chen R, Gao S, Xu Z, Li N. Li Z, et al. Pharmacol Res. 2023 Jan;187:106635. doi: 10.1016/j.phrs.2022.106635. Epub 2022 Dec 26. Pharmacol Res. 2023. PMID: 36581167 Free article. Review.
Osteoporosis is a common metabolic bone disease that results from the imbalance of homeostasis within the bone. Intra-bone homeostasis is dependent on a precise dynamic balance between bone resorption by osteoclasts and bone formation by mesenchymal lineage osteoblasts, wh …
Osteoporosis is a common metabolic bone disease that results from the imbalance of homeostasis within the bone. Intra-bone homeostasi …
Bioavailability and Cardiometabolic Effects of Xanthohumol: Evidence from Animal and Human Studies.
Neumann HF, Frank J, Venturelli S, Egert S. Neumann HF, et al. Mol Nutr Food Res. 2022 Mar;66(6):e2100831. doi: 10.1002/mnfr.202100831. Epub 2022 Jan 14. Mol Nutr Food Res. 2022. PMID: 34967501 Review.
Increasing evidence suggests that xanthohumol positively affects biomarkers associated with metabolic syndrome and cardiovascular diseases (CVDs). ...In addition, it provides insights into the pharmacokinetics of xanthohumol intake. Animal studies show that …
Increasing evidence suggests that xanthohumol positively affects biomarkers associated with metabolic syndrome and cardiovascu …
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.
Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF. Miranda CL, et al. Arch Biochem Biophys. 2016 Jun 1;599:22-30. doi: 10.1016/j.abb.2016.03.008. Epub 2016 Mar 11. Arch Biochem Biophys. 2016. PMID: 26976708 Free PMC article.
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The dose-dependent effects of XN on glucose and lipid metabolism in a preclinical model of metabolic syndrome were the focus of our study. ...Our results show that oral admin …
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The dose-dependent effects of XN on glucose and …
Gut enterotype-dependent modulation of gut microbiota and their metabolism in response to xanthohumol supplementation in healthy adults.
Jamieson PE, Smart EB, Bouranis JA, Choi J, Danczak RE, Wong CP, Paraiso IL, Maier CS, Ho E, Sharpton TJ, Metz TO, Bradley R, Stevens JF. Jamieson PE, et al. Gut Microbes. 2024 Jan-Dec;16(1):2315633. doi: 10.1080/19490976.2024.2315633. Epub 2024 Feb 15. Gut Microbes. 2024. PMID: 38358253 Free PMC article. Clinical Trial.
Xanthohumol (XN), a polyphenol found in the hop plant (Humulus lupulus), has antioxidant, anti-inflammatory, prebiotic, and anti-hyperlipidemic activity. ...High levels of inter-individual variation in metabolic profiles and bioavailability of XN metabolites were ob …
Xanthohumol (XN), a polyphenol found in the hop plant (Humulus lupulus), has antioxidant, anti-inflammatory, prebiotic, and anti-hype …
Recovery and metabolism of xanthohumol in germ-free and human microbiota-associated rats.
Hanske L, Loh G, Sczesny S, Blaut M, Braune A. Hanske L, et al. Mol Nutr Food Res. 2010 Oct;54(10):1405-13. doi: 10.1002/mnfr.200900517. Mol Nutr Food Res. 2010. PMID: 20397197
The impact of human intestinal bacteria on the bioavailability of the prenylflavonoid xanthohumol (XN) was studied by comparing germ-free (GF) and human microbiota-associated (HMA) rats. ...Thus, the impact of bacteria on the XN metabolism in the gut may affect the …
The impact of human intestinal bacteria on the bioavailability of the prenylflavonoid xanthohumol (XN) was studied by comparing germ- …
Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism.
Zhang Y, Bobe G, Revel JS, Rodrigues RR, Sharpton TJ, Fantacone ML, Raslan K, Miranda CL, Lowry MB, Blakemore PR, Morgun A, Shulzhenko N, Maier CS, Stevens JF, Gombart AF. Zhang Y, et al. Mol Nutr Food Res. 2020 Jan;64(1):e1900789. doi: 10.1002/mnfr.201900789. Epub 2019 Dec 15. Mol Nutr Food Res. 2020. PMID: 31755244 Free PMC article.
SCOPE: Two hydrogenated xanthohumol (XN) derivatives, alpha,beta-dihydro-XN (DXN) and tetrahydro-XN (TXN), improved parameters of metabolic syndrome (MetS), a critical risk factor of cardiovascular disease (CVD) and type 2 diabetes, in a diet-induced obese murine mo …
SCOPE: Two hydrogenated xanthohumol (XN) derivatives, alpha,beta-dihydro-XN (DXN) and tetrahydro-XN (TXN), improved parameters of …
468 results