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Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
Stevens JF, Page JE. Stevens JF, et al. Phytochemistry. 2004 May;65(10):1317-30. doi: 10.1016/j.phytochem.2004.04.025. Phytochemistry. 2004. PMID: 15231405 Review.
These biological activities suggest that prenylflavonoids from hops have potential for application in cancer prevention programs and in prevention or treatment of (post-)menopausal 'hot flashes' and osteoporosis. Xanthohumol and 8-prenylnaringenin are metabolized in …
These biological activities suggest that prenylflavonoids from hops have potential for application in cancer prevention programs and in prev …
Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops.
Li J, Zeng L, Xie J, Yue Z, Deng H, Ma X, Zheng C, Wu X, Luo J, Liu M. Li J, et al. Sci Rep. 2015 Dec 1;5:17605. doi: 10.1038/srep17605. Sci Rep. 2015. PMID: 26620037 Free PMC article.
In this study, we examined the effects of xanthohumol (XN), an abundant prenylflavonoid from hops plant, on osteoclastogenesis, osteoclast resorption, and RANKL-induced signaling pathway using both in vitro and in vivo assay systems. ...XN could be a promising drug candida …
In this study, we examined the effects of xanthohumol (XN), an abundant prenylflavonoid from hops plant, on osteoclastogenesis, osteo …
Effects of phytoestrogens and other plant-derived compounds on mesenchymal stem cells, bone maintenance and regeneration.
Schilling T, Ebert R, Raaijmakers N, Schütze N, Jakob F. Schilling T, et al. J Steroid Biochem Mol Biol. 2014 Jan;139:252-61. doi: 10.1016/j.jsbmb.2012.12.006. Epub 2012 Dec 20. J Steroid Biochem Mol Biol. 2014. PMID: 23262262 Review.
Phytoestrogens and other plant-derived compounds and extracts have been developed for the treatment of menopause-related complaints and disorders, e.g. hot flushes and osteoporosis. ...As a novel mechanism, phytoestrogens and plant-derived saponins and flavonoids like kaem …
Phytoestrogens and other plant-derived compounds and extracts have been developed for the treatment of menopause-related complaints and diso …
Xanthohumol modulates the expression of osteoclast-specific genes during osteoclastogenesis in RAW264.7 cells.
Suh KS, Rhee SY, Kim YS, Lee YS, Choi EM. Suh KS, et al. Food Chem Toxicol. 2013 Dec;62:99-106. doi: 10.1016/j.fct.2013.08.047. Epub 2013 Aug 27. Food Chem Toxicol. 2013. PMID: 23994090
Xanthohumol markedly inhibited RANKL-induced TRAP activity, multinucleated osteoclasts formation, and resorption-pit formation. ...These data demonstrate that xanthohumol inhibits osteoclastogenesis by modulating RANKL signaling and may be useful for the prevention
Xanthohumol markedly inhibited RANKL-induced TRAP activity, multinucleated osteoclasts formation, and resorption-pit formation. ...Th
Xanthohumol from the hop plant stimulates osteoblast differentiation by RUNX2 activation.
Jeong HM, Han EH, Jin YH, Choi YH, Lee KY, Jeong HG. Jeong HM, et al. Biochem Biophys Res Commun. 2011 May 27;409(1):82-9. doi: 10.1016/j.bbrc.2011.04.113. Epub 2011 May 1. Biochem Biophys Res Commun. 2011. PMID: 21565172
Xanthohumol (XN), the principal prenylated flavonoid from the hop plant, an additive that contributes bitterness and flavor to beer, is known to be a potent phytoestrogen. ...Regulation of RUNX2 activation by XN may be an important therapeutic target for osteoporosis
Xanthohumol (XN), the principal prenylated flavonoid from the hop plant, an additive that contributes bitterness and flavor to beer,
Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens.
Effenberger KE, Johnsen SA, Monroe DG, Spelsberg TC, Westendorf JJ. Effenberger KE, et al. J Steroid Biochem Mol Biol. 2005 Sep;96(5):387-99. doi: 10.1016/j.jsbmb.2005.04.038. Epub 2005 Jul 12. J Steroid Biochem Mol Biol. 2005. PMID: 16019205
In the current study, we tested the effects of the hop-derived compounds 8-prenylnaringenin, 6-prenylnaringenin, xanthohumol and isoxanthohumol (1) to modulate markers of differentiation and gene expression in osteoblasts and (2) to regulate proliferation in MCF-7 breast c …
In the current study, we tested the effects of the hop-derived compounds 8-prenylnaringenin, 6-prenylnaringenin, xanthohumol and isox …
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