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Cell death regulation: A new way for natural products to treat osteoporosis.
Li Z, Li D, Chen R, Gao S, Xu Z, Li N. Li Z, et al. Pharmacol Res. 2023 Jan;187:106635. doi: 10.1016/j.phrs.2022.106635. Epub 2022 Dec 26. Pharmacol Res. 2023. PMID: 36581167 Free article. Review.
Osteoporosis is a common metabolic bone disease that results from the imbalance of homeostasis within the bone. ...Based on this, this review provides more insights into new molecular mechanisms of osteoporosis and provides a reference for developing more natural an …
Osteoporosis is a common metabolic bone disease that results from the imbalance of homeostasis within the bone. ...Based on this, thi …
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
Stevens JF, Page JE. Stevens JF, et al. Phytochemistry. 2004 May;65(10):1317-30. doi: 10.1016/j.phytochem.2004.04.025. Phytochemistry. 2004. PMID: 15231405 Review.
Human exposure to xanthohumol and related prenylflavonoids, such as 8-prenylnaringenin and isoxanthohumol, is primarily through beer consumption. ...These biological activities suggest that prenylflavonoids from hops have potential for application in cancer prevention prog …
Human exposure to xanthohumol and related prenylflavonoids, such as 8-prenylnaringenin and isoxanthohumol, is primarily through beer …
Hops extract and xanthohumol ameliorate bone loss induced by iron overload via activating Akt/GSK3β/Nrf2 pathway.
Sun X, Xia T, Zhang S, Zhang J, Xu L, Han T, Xin H. Sun X, et al. J Bone Miner Metab. 2022 May;40(3):375-388. doi: 10.1007/s00774-021-01295-2. Epub 2022 Feb 1. J Bone Miner Metab. 2022. PMID: 35106609
INTRODUCTION: Osteoporosis is closely related to iron metabolism. This study aimed to investigate whether hops extract (HLE) and its active component xanthohumol (XAN) could ameliorate bone loss caused by iron overload, and explored its potential mechanism. ...Furth …
INTRODUCTION: Osteoporosis is closely related to iron metabolism. This study aimed to investigate whether hops extract (HLE) and its …
Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops.
Li J, Zeng L, Xie J, Yue Z, Deng H, Ma X, Zheng C, Wu X, Luo J, Liu M. Li J, et al. Sci Rep. 2015 Dec 1;5:17605. doi: 10.1038/srep17605. Sci Rep. 2015. PMID: 26620037 Free PMC article.
Therefore, targeting RANKL or its signaling pathway has been a promising and successful strategy for this osteoclast-related diseases. In this study, we examined the effects of xanthohumol (XN), an abundant prenylflavonoid from hops plant, on osteoclastogenesis, osteoclast …
Therefore, targeting RANKL or its signaling pathway has been a promising and successful strategy for this osteoclast-related diseases. In th …
PI3K/AKT/Nrf2 signalling pathway is involved in the ameliorative effects of xanthohumol on amyloid β-induced oxidative damage and bone loss.
Xia T, Liu X, Wang N, Jiang Y, Bai H, Xu W, Feng K, Han T, Xin H. Xia T, et al. J Pharm Pharmacol. 2022 Jul 15;74(7):1017-1026. doi: 10.1093/jpp/rgac007. J Pharm Pharmacol. 2022. PMID: 35353176
OBJECTIVE: Xanthohumol (XAN), a natural isoflavone from Humulus lupulus L., possesses biological activities on relieving oxidative stress and osteoporosis (OP). ...
OBJECTIVE: Xanthohumol (XAN), a natural isoflavone from Humulus lupulus L., possesses biological activities on relieving oxidative st …
Effects of phytoestrogens and other plant-derived compounds on mesenchymal stem cells, bone maintenance and regeneration.
Schilling T, Ebert R, Raaijmakers N, Schütze N, Jakob F. Schilling T, et al. J Steroid Biochem Mol Biol. 2014 Jan;139:252-61. doi: 10.1016/j.jsbmb.2012.12.006. Epub 2012 Dec 20. J Steroid Biochem Mol Biol. 2014. PMID: 23262262 Review.
Phytoestrogens and other plant-derived compounds and extracts have been developed for the treatment of menopause-related complaints and disorders, e.g. hot flushes and osteoporosis. Since estrogens have been discussed to enhance the risk for hormone-sensitive cancers, rese …
Phytoestrogens and other plant-derived compounds and extracts have been developed for the treatment of menopause-related complaints and diso …
Xanthohumol modulates the expression of osteoclast-specific genes during osteoclastogenesis in RAW264.7 cells.
Suh KS, Rhee SY, Kim YS, Lee YS, Choi EM. Suh KS, et al. Food Chem Toxicol. 2013 Dec;62:99-106. doi: 10.1016/j.fct.2013.08.047. Epub 2013 Aug 27. Food Chem Toxicol. 2013. PMID: 23994090
Xanthohumol markedly inhibited RANKL-induced TRAP activity, multinucleated osteoclasts formation, and resorption-pit formation. ...These data demonstrate that xanthohumol inhibits osteoclastogenesis by modulating RANKL signaling and may be useful for the prevention …
Xanthohumol markedly inhibited RANKL-induced TRAP activity, multinucleated osteoclasts formation, and resorption-pit formation. ...Th …
A comprehensive review of the benefits of drinking craft beer: Role of phenolic content in health and possible potential of the alcoholic fraction.
Tirado-Kulieva VA, Hernández-Martínez E, Minchán-Velayarce HH, Pasapera-Campos SE, Luque-Vilca OM. Tirado-Kulieva VA, et al. Curr Res Food Sci. 2023 Mar 4;6:100477. doi: 10.1016/j.crfs.2023.100477. eCollection 2023. Curr Res Food Sci. 2023. PMID: 36935850 Free PMC article. Review.
Thus, studies in vitro, with animal models and clinical trials on cardiovascular and neurodegenerative diseases, cancer, diabetes and obesity, osteoporosis and even the immune system suggest the consumption of craft beer. ...
Thus, studies in vitro, with animal models and clinical trials on cardiovascular and neurodegenerative diseases, cancer, diabetes and obesit …
Xanthohumol from the hop plant stimulates osteoblast differentiation by RUNX2 activation.
Jeong HM, Han EH, Jin YH, Choi YH, Lee KY, Jeong HG. Jeong HM, et al. Biochem Biophys Res Commun. 2011 May 27;409(1):82-9. doi: 10.1016/j.bbrc.2011.04.113. Epub 2011 May 1. Biochem Biophys Res Commun. 2011. PMID: 21565172
Xanthohumol (XN), the principal prenylated flavonoid from the hop plant, an additive that contributes bitterness and flavor to beer, is known to be a potent phytoestrogen. ...Regulation of RUNX2 activation by XN may be an important therapeutic target for osteoporosis …
Xanthohumol (XN), the principal prenylated flavonoid from the hop plant, an additive that contributes bitterness and flavor to beer, …
Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens.
Effenberger KE, Johnsen SA, Monroe DG, Spelsberg TC, Westendorf JJ. Effenberger KE, et al. J Steroid Biochem Mol Biol. 2005 Sep;96(5):387-99. doi: 10.1016/j.jsbmb.2005.04.038. Epub 2005 Jul 12. J Steroid Biochem Mol Biol. 2005. PMID: 16019205
Certain plant-derived compounds show selective estrogen receptor modulator (SERM) activity and may therefore be an alternative to the conventional hormone replacement therapy, which prevents osteoporosis but is also associated with an increased risk of breast and endometri …
Certain plant-derived compounds show selective estrogen receptor modulator (SERM) activity and may therefore be an alternative to the conven …