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Unravelling the pathogenesis of inflammatory bowel disease.
Xavier RJ, Podolsky DK. Xavier RJ, et al. Nature. 2007 Jul 26;448(7152):427-34. doi: 10.1038/nature06005. Nature. 2007. PMID: 17653185 Review.
Peroxynitrite-induced rat colitis--a new model of colonic inflammation.
Rachmilewitz D, Stamler JS, Karmeli F, Mullins ME, Singel DJ, Loscalzo J, Xavier RJ, Podolsky DK. Rachmilewitz D, et al. Gastroenterology. 1993 Dec;105(6):1681-8. doi: 10.1016/0016-5085(93)91063-n. Gastroenterology. 1993. PMID: 8253344
Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa.
Muehlhoefer A, Saubermann LJ, Gu X, Luedtke-Heckenkamp K, Xavier R, Blumberg RS, Podolsky DK, MacDermott RP, Reinecker HC. Muehlhoefer A, et al. J Immunol. 2000 Mar 15;164(6):3368-76. doi: 10.4049/jimmunol.164.6.3368. J Immunol. 2000. PMID: 10706732
Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice.
Beck PL, Xavier R, Lu N, Nanda NN, Dinauer M, Podolsky DK, Seed B. Beck PL, et al. Gastroenterology. 2000 Sep;119(3):699-705. doi: 10.1053/gast.2000.16497. Gastroenterology. 2000. PMID: 10982764
Microbiology. How to get along--friendly microbes in a hostile world.
Xavier RJ, Podolsky DK. Xavier RJ, et al. Science. 2000 Sep 1;289(5484):1483-4. doi: 10.1126/science.289.5484.1483. Science. 2000. PMID: 10991734
As Xavier and Podolsky explain in their Perspective, this may be because bacteria that are indigenous to the gut have learned ways to switch off pathways in gut epithelial cells that lead to switching on of genes involved in inflammation (Neish et al.)....
As Xavier and Podolsky explain in their Perspective, this may be because bacteria that are indigenous to the gut have learned ways to …
Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.
Mizoguchi E, Mizoguchi A, Takedatsu H, Cario E, de Jong YP, Ooi CJ, Xavier RJ, Terhorst C, Podolsky DK, Bhan AK. Mizoguchi E, et al. Gastroenterology. 2002 Jan;122(1):134-44. doi: 10.1053/gast.2002.30347. Gastroenterology. 2002. PMID: 11781288
Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells.
Beck PL, Rosenberg IM, Xavier RJ, Koh T, Wong JF, Podolsky DK. Beck PL, et al. Am J Pathol. 2003 Feb;162(2):597-608. doi: 10.1016/s0002-9440(10)63853-9. Am J Pathol. 2003. PMID: 12547717 Free PMC article.
Colonic epithelial functional phenotype varies with type and phase of experimental colitis.
Mizoguchi E, Xavier RJ, Reinecker HC, Uchino H, Bhan AK, Podolsky DK, Mizoguchi A. Mizoguchi E, et al. Gastroenterology. 2003 Jul;125(1):148-61. doi: 10.1016/s0016-5085(03)00665-6. Gastroenterology. 2003. PMID: 12851880
Paradoxical roles of different nitric oxide synthase isoforms in colonic injury.
Beck PL, Xavier R, Wong J, Ezedi I, Mashimo H, Mizoguchi A, Mizoguchi E, Bhan AK, Podolsky DK. Beck PL, et al. Am J Physiol Gastrointest Liver Physiol. 2004 Jan;286(1):G137-47. doi: 10.1152/ajpgi.00309.2003. Am J Physiol Gastrointest Liver Physiol. 2004. PMID: 14665440
GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells.
Barnich N, Hisamatsu T, Aguirre JE, Xavier R, Reinecker HC, Podolsky DK. Barnich N, et al. J Biol Chem. 2005 May 13;280(19):19021-6. doi: 10.1074/jbc.M413776200. Epub 2005 Mar 7. J Biol Chem. 2005. PMID: 15753091
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