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A Common Mechanism Links Activities of Butyrate in the Colon.
Verma MS, Fink MJ, Salmon GL, Fornelos N, Ohara TE, Ryu SH, Vlamakis H, Xavier RJ, Stappenbeck TS, Whitesides GM. Verma MS, et al. Among authors: xavier rj. ACS Chem Biol. 2018 May 18;13(5):1291-1298. doi: 10.1021/acschembio.8b00073. Epub 2018 Apr 10. ACS Chem Biol. 2018. PMID: 29584955
Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter.
Mahoney ZX, Sammut B, Xavier RJ, Cunningham J, Go G, Brim KL, Stappenbeck TS, Miner JH, Swat W. Mahoney ZX, et al. Among authors: xavier rj. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19872-7. doi: 10.1073/pnas.0609326103. Epub 2006 Dec 15. Proc Natl Acad Sci U S A. 2006. PMID: 17172448 Free PMC article.
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th. Cadwell K, et al. Among authors: xavier rj. Nature. 2008 Nov 13;456(7219):259-63. doi: 10.1038/nature07416. Epub 2008 Oct 5. Nature. 2008. PMID: 18849966 Free PMC article.
Crohn disease: a current perspective on genetics, autophagy and immunity.
Stappenbeck TS, Rioux JD, Mizoguchi A, Saitoh T, Huett A, Darfeuille-Michaud A, Wileman T, Mizushima N, Carding S, Akira S, Parkes M, Xavier RJ. Stappenbeck TS, et al. Among authors: xavier rj. Autophagy. 2011 Apr;7(4):355-74. doi: 10.4161/auto.7.2.13074. Epub 2011 Apr 1. Autophagy. 2011. PMID: 20729636 Free PMC article. Review.
Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.
Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ. Conway KL, et al. Among authors: xavier rj. Gastroenterology. 2013 Dec;145(6):1347-57. doi: 10.1053/j.gastro.2013.08.035. Epub 2013 Aug 21. Gastroenterology. 2013. PMID: 23973919 Free PMC article.
Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.
Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ. Shaw SY, et al. Among authors: xavier rj. ACS Chem Biol. 2013 Dec 20;8(12):2724-2733. doi: 10.1021/cb400352d. Epub 2013 Oct 29. ACS Chem Biol. 2013. PMID: 24168452 Free PMC article.
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.
Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ. Lassen KG, et al. Among authors: xavier rj. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6. doi: 10.1073/pnas.1407001111. Epub 2014 May 12. Proc Natl Acad Sci U S A. 2014. PMID: 24821797 Free PMC article.
Disease-specific alterations in the enteric virome in inflammatory bowel disease.
Norman JM, Handley SA, Baldridge MT, Droit L, Liu CY, Keller BC, Kambal A, Monaco CL, Zhao G, Fleshner P, Stappenbeck TS, McGovern DP, Keshavarzian A, Mutlu EA, Sauk J, Gevers D, Xavier RJ, Wang D, Parkes M, Virgin HW. Norman JM, et al. Among authors: xavier rj. Cell. 2015 Jan 29;160(3):447-60. doi: 10.1016/j.cell.2015.01.002. Epub 2015 Jan 22. Cell. 2015. PMID: 25619688 Free PMC article.
620 results