Xia W - Search Results

1

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Wolfe MS, et al. Among authors: xia w. Nature. 1999 Apr 8;398(6727):513-7. doi: 10.1038/19077. Nature. 1999. PMID: 10206644

2

Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase.

Campbell WA, Reed ML, Strahle J, Wolfe MS, Xia W. Campbell WA, et al. Among authors: xia w. J Neurochem. 2003 Jun;85(6):1563-74. doi: 10.1046/j.1471-4159.2003.01799.x. J Neurochem. 2003. PMID: 12787075 Free article.

3

Intramembrane proteolysis by presenilin and presenilin-like proteases.

Xia W, Wolfe MS. Xia W, et al. J Cell Sci. 2003 Jul 15;116(Pt 14):2839-44. doi: 10.1242/jcs.00651. J Cell Sci. 2003. PMID: 12808018 Review.

4

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates.

Baulac S, LaVoie MJ, Kimberly WT, Strahle J, Wolfe MS, Selkoe DJ, Xia W. Baulac S, et al. Among authors: xia w. Neurobiol Dis. 2003 Nov;14(2):194-204. doi: 10.1016/s0969-9961(03)00123-2. Neurobiol Dis. 2003. PMID: 14572442

5

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.

Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ. Citron M, et al. Among authors: xia w. Nat Med. 1997 Jan;3(1):67-72. doi: 10.1038/nm0197-67. Nat Med. 1997. PMID: 8986743

6

Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.

Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Podlisny MB, et al. Among authors: xia w. Neurobiol Dis. 1997;3(4):325-37. doi: 10.1006/nbdi.1997.0129. Neurobiol Dis. 1997. PMID: 9173929

7

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.

Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. Xia W, et al. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8208-13. doi: 10.1073/pnas.94.15.8208. Proc Natl Acad Sci U S A. 1997. PMID: 9223340 Free PMC article.

8

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

Wolfe MS, Citron M, Diehl TS, Xia W, Donkor IO, Selkoe DJ. Wolfe MS, et al. Among authors: xia w. J Med Chem. 1998 Jan 1;41(1):6-9. doi: 10.1021/jm970621b. J Med Chem. 1998. PMID: 9438016 No abstract available.

9

Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ. Citron M, et al. Among authors: xia w. Neurobiol Dis. 1998 Aug;5(2):107-16. doi: 10.1006/nbdi.1998.0183. Neurobiol Dis. 1998. PMID: 9746908

10

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Xia W, et al. Biochemistry. 1998 Nov 24;37(47):16465-71. doi: 10.1021/bi9816195. Biochemistry. 1998. PMID: 9843412

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