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Using native chromatin immunoprecipitation to interrogate histone variant protein deposition in embryonic stem cells.
Tseng Z, Wu T, Liu Y, Zhong M, Xiao A. Tseng Z, et al. Methods Mol Biol. 2014;1176:11-22. doi: 10.1007/978-1-4939-0992-6_2. Methods Mol Biol. 2014. PMID: 25030915
Chromatin immunoprecipitation combined with massive parallel sequencing (ChIP-Seq) is a powerful epigenetics technique for interrogating the genome-wide localization of histone modifications, histone variants, and other chromatin-associating factors. ...Here, we describe t …
Chromatin immunoprecipitation combined with massive parallel sequencing (ChIP-Seq) is a powerful epigenetics technique for interrogat …
N(6)-Methyladenine in eukaryotes.
Alderman MH 3rd, Xiao AZ. Alderman MH 3rd, et al. Cell Mol Life Sci. 2019 Aug;76(15):2957-2966. doi: 10.1007/s00018-019-03146-w. Epub 2019 May 29. Cell Mol Life Sci. 2019. PMID: 31143960 Free PMC article. Review.
DNA modifications are a major form of epigenetic regulation that eukaryotic cells utilize in concert with histone modifications. ...
DNA modifications are a major form of epigenetic regulation that eukaryotic cells utilize in concert with histone modifications. ...
DNA methylation on N(6)-adenine in mammalian embryonic stem cells.
Wu TP, Wang T, Seetin MG, Lai Y, Zhu S, Lin K, Liu Y, Byrum SD, Mackintosh SG, Zhong M, Tackett A, Wang G, Hon LS, Fang G, Swenberg JA, Xiao AZ. Wu TP, et al. Nature. 2016 Apr 21;532(7599):329-33. doi: 10.1038/nature17640. Epub 2016 Mar 30. Nature. 2016. PMID: 27027282 Free PMC article.
Alkbh1 encodes a demethylase for N(6)-methyladenine. An increase of N(6)-methyladenine levels in Alkbh1-deficient cells leads to transcriptional silencing. ...Our results demonstrate that N(6)-methyladenine constitutes a crucial component of the epigenetic regulatio …
Alkbh1 encodes a demethylase for N(6)-methyladenine. An increase of N(6)-methyladenine levels in Alkbh1-deficient cells leads to tran …
Quality control towards the application of induced pluripotent stem cells.
Lin K, Xiao AZ. Lin K, et al. Curr Opin Genet Dev. 2017 Oct;46:164-169. doi: 10.1016/j.gde.2017.07.006. Epub 2017 Aug 18. Curr Opin Genet Dev. 2017. PMID: 28823985 Review.
Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.
Choi J, Huebner AJ, Clement K, Walsh RM, Savol A, Lin K, Gu H, Di Stefano B, Brumbaugh J, Kim SY, Sharif J, Rose CM, Mohammad A, Odajima J, Charron J, Shioda T, Gnirke A, Gygi S, Koseki H, Sadreyev RI, Xiao A, Meissner A, Hochedlinger K. Choi J, et al. Nature. 2017 Aug 10;548(7666):219-223. doi: 10.1038/nature23274. Epub 2017 Jul 26. Nature. 2017. PMID: 28746311 Free PMC article.
Concomitant activation of the Wnt pathway and suppression of Mapk signalling by two small molecule inhibitors (2i) in the presence of leukaemia inhibitory factor (LIF) (hereafter termed 2i/L) induces a naive state in mouse embryonic stem (ES) cells that resembles the inner …
Concomitant activation of the Wnt pathway and suppression of Mapk signalling by two small molecule inhibitors (2i) in the presence of leukae …
Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-like Cells.
Benchetrit H, Herman S, van Wietmarschen N, Wu T, Makedonski K, Maoz N, Yom Tov N, Stave D, Lasry R, Zayat V, Xiao A, Lansdorp PM, Sebban S, Buganim Y. Benchetrit H, et al. Cell Stem Cell. 2015 Nov 5;17(5):543-56. doi: 10.1016/j.stem.2015.08.006. Epub 2015 Sep 24. Cell Stem Cell. 2015. PMID: 26412562
However, direct conversion of cells from one lineage to another often yields incompletely reprogrammed, functionally compromised cells, raising the question of whether pluripotency is required to achieve a high degree of nuclear reprogramming. Here, we show that transient …
However, direct conversion of cells from one lineage to another often yields incompletely reprogrammed, functionally compromised cells, rais …
Adaption by Rewiring Epigenetic Landscapes.
Liu Y, Xiao A. Liu Y, et al. Cell Stem Cell. 2015 Sep 3;17(3):249-50. doi: 10.1016/j.stem.2015.08.015. Cell Stem Cell. 2015. PMID: 26340521 Free PMC article.
The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.
Buganim Y, Markoulaki S, van Wietmarschen N, Hoke H, Wu T, Ganz K, Akhtar-Zaidi B, He Y, Abraham BJ, Porubsky D, Kulenkampff E, Faddah DA, Shi L, Gao Q, Sarkar S, Cohen M, Goldmann J, Nery JR, Schultz MD, Ecker JR, Xiao A, Young RA, Lansdorp PM, Jaenisch R. Buganim Y, et al. Cell Stem Cell. 2014 Sep 4;15(3):295-309. doi: 10.1016/j.stem.2014.07.003. Cell Stem Cell. 2014. PMID: 25192464 Free PMC article.
Histone variant H2A.X deposition pattern serves as a functional epigenetic mark for distinguishing the developmental potentials of iPSCs.
Wu T, Liu Y, Wen D, Tseng Z, Tahmasian M, Zhong M, Rafii S, Stadtfeld M, Hochedlinger K, Xiao A. Wu T, et al. Cell Stem Cell. 2014 Sep 4;15(3):281-294. doi: 10.1016/j.stem.2014.06.004. Cell Stem Cell. 2014. PMID: 25192463
Here we show that the histone variant H2A.X is a functional marker that can distinguish the developmental potentials of mouse iPSC lines. ...In contrast, iPSCs that fail to support all-iPS embryonic development show aberrant H2A.X deposition, upregulation of extraembryonic …
Here we show that the histone variant H2A.X is a functional marker that can distinguish the developmental potentials of mouse iPSC li …
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