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Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.
Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA. Borghese CM, et al. J Pharmacol Exp Ther. 2012 Feb;340(2):304-16. doi: 10.1124/jpet.111.185116. Epub 2011 Oct 28. J Pharmacol Exp Ther. 2012. PMID: 22037201 Free PMC article.
Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.
Borghese CM, Xiong W, Oh SI, Ho A, Mihic SJ, Zhang L, Lovinger DM, Homanics GE, Eger EI 2nd, Harris RA. Borghese CM, et al. Anesthesiology. 2012 Oct;117(4):765-71. doi: 10.1097/ALN.0b013e31826a0d93. Anesthesiology. 2012. PMID: 22885675 Free PMC article.
Loss of metabotropic glutamate receptor 2 escalates alcohol consumption.
Zhou Z, Karlsson C, Liang T, Xiong W, Kimura M, Tapocik JD, Yuan Q, Barbier E, Feng A, Flanigan M, Augier E, Enoch MA, Hodgkinson CA, Shen PH, Lovinger DM, Edenberg HJ, Heilig M, Goldman D. Zhou Z, et al. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16963-8. doi: 10.1073/pnas.1309839110. Epub 2013 Sep 30. Proc Natl Acad Sci U S A. 2013. PMID: 24082084 Free PMC article.
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