Xu J - Search Results

1

Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch.

Liu N, Hargreaves VV, Zhu Q, Kurland JV, Hong J, Kim W, Sher F, Macias-Trevino C, Rogers JM, Kurita R, Nakamura Y, Yuan GC, Bauer DE, Xu J, Bulyk ML, Orkin SH. Liu N, et al. Among authors: xu j. Cell. 2018 Apr 5;173(2):430-442.e17. doi: 10.1016/j.cell.2018.03.016. Epub 2018 Mar 29. Cell. 2018. PMID: 29606353 Free PMC article.

2

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH. Sankaran VG, et al. Among authors: xu j. Science. 2008 Dec 19;322(5909):1839-42. doi: 10.1126/science.1165409. Epub 2008 Dec 4. Science. 2008. PMID: 19056937

3

Developmental and species-divergent globin switching are driven by BCL11A.

Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH. Sankaran VG, et al. Among authors: xu j. Nature. 2009 Aug 27;460(7259):1093-7. doi: 10.1038/nature08243. Epub 2009 Aug 5. Nature. 2009. PMID: 19657335 Free PMC article.

4

Advances in the understanding of haemoglobin switching.

Sankaran VG, Xu J, Orkin SH. Sankaran VG, et al. Among authors: xu j. Br J Haematol. 2010 Apr;149(2):181-94. doi: 10.1111/j.1365-2141.2010.08105.x. Epub 2010 Mar 1. Br J Haematol. 2010. PMID: 20201948 Free PMC article. Review.

5

Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.

Xu J, Sankaran VG, Ni M, Menne TF, Puram RV, Kim W, Orkin SH. Xu J, et al. Genes Dev. 2010 Apr 15;24(8):783-98. doi: 10.1101/gad.1897310. Genes Dev. 2010. PMID: 20395365 Free PMC article.

6

Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP).

Snow JW, Kim J, Currie CR, Xu J, Orkin SH. Snow JW, et al. Among authors: xu j. J Biol Chem. 2010 Sep 3;285(36):28064-75. doi: 10.1074/jbc.M109.096909. Epub 2010 Jun 28. J Biol Chem. 2010. PMID: 20587419 Free PMC article.

7

Transcriptional silencing of fetal hemoglobin by BCL11A.

Sankaran VG, Xu J, Orkin SH. Sankaran VG, et al. Among authors: xu j. Ann N Y Acad Sci. 2010 Aug;1202:64-8. doi: 10.1111/j.1749-6632.2010.05574.x. Ann N Y Acad Sci. 2010. PMID: 20712774

8

The erythroid/myeloid lineage fate paradigm takes a new player.

Xu J, Orkin SH. Xu J, et al. EMBO J. 2011 Mar 16;30(6):983-5. doi: 10.1038/emboj.2011.45. EMBO J. 2011. PMID: 21407249 Free PMC article.

9

A functional element necessary for fetal hemoglobin silencing.

Sankaran VG, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA. Sankaran VG, et al. Among authors: xu j. N Engl J Med. 2011 Sep 1;365(9):807-14. doi: 10.1056/NEJMoa1103070. N Engl J Med. 2011. PMID: 21879898 Free PMC article.

10

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing.

Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH. Xu J, et al. Science. 2011 Nov 18;334(6058):993-6. doi: 10.1126/science.1211053. Epub 2011 Oct 13. Science. 2011. PMID: 21998251 Free PMC article.

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