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GSDMD-dependent neutrophil extracellular traps promote macrophage-to-myofibroblast transition and renal fibrosis in obstructive nephropathy.
Wang Y, Li Y, Chen Z, Yuan Y, Su Q, Ye K, Chen C, Li G, Song Y, Chen H, Xu Y. Wang Y, et al. Cell Death Dis. 2022 Aug 8;13(8):693. doi: 10.1038/s41419-022-05138-4. Cell Death Dis. 2022. PMID: 35941120 Free PMC article.
Gsdmd deletion significantly reduced infiltration of inflammatory cells in the kidneys and inhibited NETs formation, MMT and thereby renal fibrosis. Chimera studies confirmed that Gsdmd deletion in bone marrow-derived cells, instead of renal parenchymal cells
Gsdmd deletion significantly reduced infiltration of inflammatory cells in the kidneys and inhibited NETs formation, MMT and thereby …
Penetrating Macrophage-Based Nanoformulation for Periodontitis Treatment.
Yan N, Xu J, Liu G, Ma C, Bao L, Cong Y, Wang Z, Zhao Y, Xu W, Chen C. Yan N, et al. ACS Nano. 2022 Nov 22;16(11):18253-18265. doi: 10.1021/acsnano.2c05923. Epub 2022 Oct 26. ACS Nano. 2022. PMID: 36288552
On the one hand, P.g. inhibits phagocytosis and the killing capacity of immune cells. On the other hand, P.g. increases selective cytokine release, which is beneficial to its further proliferation. ...Meanwhile, MZ@PNM interrupted the specific binding of P.g. to immune …
On the one hand, P.g. inhibits phagocytosis and the killing capacity of immune cells. On the other hand, P.g. increases selective cyt …
Retraction.
[No authors listed] [No authors listed] J Cell Physiol. 2022 Nov;237(11):4328. doi: 10.1002/jcp.30894. Epub 2022 Oct 20. J Cell Physiol. 2022. PMID: 36264170
Retraction: "Effects of IGFBP3 gene silencing mediated inhibition of ERK/MAPK signaling pathway on proliferation, apoptosis, autophagy, and cell senescence in rats nucleus pulposus cells," by Gang Chen, Xiaopeng Zhou, and Zhengkuan Xu, J Cell Physiol. 2019; 9308-931 …
Retraction: "Effects of IGFBP3 gene silencing mediated inhibition of ERK/MAPK signaling pathway on proliferation, apoptosis, autophagy, and …
Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.
Zhang X, Zhang C, Qiao M, Cheng C, Tang N, Lu S, Sun W, Xu B, Cao Y, Wei X, Wang Y, Han W, Wang H. Zhang X, et al. Cancer Cell. 2022 Nov 14;40(11):1407-1422.e7. doi: 10.1016/j.ccell.2022.09.013. Epub 2022 Oct 13. Cancer Cell. 2022. PMID: 36240777 Free article.
To address this challenge, we performed a candidate gene screen using a hypofunction CAR-T cell model and found that depletion of basic leucine zipper ATF-like transcription factor (BATF) improved the antitumor performance of CAR-T cells. In different types of CAR-T cel
To address this challenge, we performed a candidate gene screen using a hypofunction CAR-T cell model and found that depletion of basic leuc …
CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapy.
Li X, Lu M, Yuan M, Ye J, Zhang W, Xu L, Wu X, Hui B, Yang Y, Wei B, Guo C, Wei M, Dong J, Wu X, Gu Y. Li X, et al. Oncoimmunology. 2022 Aug 31;11(1):2118210. doi: 10.1080/2162402X.2022.2118210. eCollection 2022. Oncoimmunology. 2022. PMID: 36092638 Free PMC article.
Through intratumoural injection, the continuous expression of the functional chemokine CXCL10 in the TME is realized to recruit more CXCR3(+) T cells into the TME to kill tumor cells, and the recombinant adenovirus shows great power to 'fire up' the TME and enhance …
Through intratumoural injection, the continuous expression of the functional chemokine CXCL10 in the TME is realized to recruit more CXCR3(+ …
Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics.
Gao S, Shi Q, Zhang Y, Liang G, Kang Z, Huang B, Ma D, Wang L, Jiao J, Fang X, Xu CR, Liu L, Xu X, Göttgens B, Li C, Liu F. Gao S, et al. Cell Res. 2022 Jan;32(1):38-53. doi: 10.1038/s41422-021-00540-7. Epub 2021 Aug 2. Cell Res. 2022. PMID: 34341490 Free PMC article.
Moreover, by employing integrative analysis of single-cell and spatial transcriptomics, we identified novel HSC/MPP 'pocket-like' units (HSC PLUS), composed of niche cells (hepatoblasts, stromal cells, endothelial cells, and macrophages) and enriched with gro …
Moreover, by employing integrative analysis of single-cell and spatial transcriptomics, we identified novel HSC/MPP 'pocket-like' units (HSC …
Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice.
Shi L, Li Y, Xu X, Cheng Y, Meng B, Xu J, Xiang L, Zhang J, He K, Tong J, Zhang J, Xiang L, Xiang G. Shi L, et al. Nat Metab. 2022 Nov;4(11):1573-1590. doi: 10.1038/s42255-022-00671-0. Epub 2022 Nov 18. Nat Metab. 2022. Retraction in: Nat Metab. 2025 Jul;7(7):1493. doi: 10.1038/s42255-025-01344-4. PMID: 36400933 Free PMC article. Retracted.
BAT-specific Nrg4 restoration alleviates vascular inflammation and adhesion responses, attenuates leukocyte homing and reduces endothelial injury and atherosclerosis in male mice. In endothelial cells, Nrg4 decreases apoptosis, inflammation and adhesion responses induced b …
BAT-specific Nrg4 restoration alleviates vascular inflammation and adhesion responses, attenuates leukocyte homing and reduces endothelial i …
Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment.
Liang Y, Xu X, Xu L, Iqbal Z, Ouyang K, Zhang H, Wen C, Duan L, Xia J. Liang Y, et al. Theranostics. 2022 Jun 21;12(11):4866-4878. doi: 10.7150/thno.69368. eCollection 2022. Theranostics. 2022. PMID: 35836795 Free PMC article.
Rationale: A cell-specific delivery vehicle is required to achieve gene editing of the disease-associated cells, so the hereditable genome editing reactions are confined within these cells without affecting healthy cells. ...
Rationale: A cell-specific delivery vehicle is required to achieve gene editing of the disease-associated cells, so the hereditable g …
miR-301a Deficiency Attenuates the Macrophage Migration and Phagocytosis through YY1/CXCR4 Pathway.
Xu J, Fu L, Deng J, Zhang J, Zou Y, Liao L, Ma X, Li Z, Xu Y, Xu Y, Xu S, Liu J, Wang X, Ma X, Guo J. Xu J, et al. Cells. 2022 Dec 7;11(24):3952. doi: 10.3390/cells11243952. Cells. 2022. PMID: 36552718 Free PMC article.
(1) Background: the miR-301a is well known involving the proliferation and migration of tumor cells. However, the role of miR-301a in the migration and phagocytosis of macrophages is still unclear. (2) Methods: sciatic nerve injury, liver injury models, as well as primary …
(1) Background: the miR-301a is well known involving the proliferation and migration of tumor cells. However, the role of miR-301a in …
The heterogeneity of fibrosis and angiogenesis in endometriosis revealed by single-cell RNA-sequencing.
Zhu S, Wang A, Xu W, Hu L, Sun J, Wang X. Zhu S, et al. Biochim Biophys Acta Mol Basis Dis. 2023 Feb;1869(2):166602. doi: 10.1016/j.bbadis.2022.166602. Epub 2022 Nov 15. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 36400338 Free article.
We found that (i) The proportion of myofibroblasts, pericytes, endothelial cells and macrophages in ECE overwhelms that of non-ectopic tissues (EUE and NOE), and Myofibro.C2 was the predominant myofibroblast sub-cluster in ECE. ...(iv) The increased inflammation score, dec …
We found that (i) The proportion of myofibroblasts, pericytes, endothelial cells and macrophages in ECE overwhelms that of non-ectopi …
1,306 results