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7β-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues.
Sun HJ, Wang YH, Yuan CM, Kong LH, Xu XJ, Wang YJ, Wu HH, Lin C, Qian YY, Huang HM, Xiao L, Liu X, He Q, Fang SY, Xue DQ, Yang XC, Chen H, Zheng YL, Zheng L, Yu LQ, Xie Q, Fu W, Li W, Liu JG, Qiu ZB, Shao LM. Sun HJ, et al. Among authors: xue dq. Bioorg Med Chem. 2018 Aug 7;26(14):4254-4263. doi: 10.1016/j.bmc.2018.07.020. Epub 2018 Jul 24. Bioorg Med Chem. 2018. PMID: 30054192
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