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Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes.
Gazi L, Gyles S, Rose J, Lees S, Allan C, Xue L, Jassal R, Speight G, Gamble V, Pettipher R. Gazi L, et al. Among authors: Xue L. Prostaglandins Other Lipid Mediat. 2005 Jan;75(1-4):153-67. doi: 10.1016/j.prostaglandins.2004.11.003. Prostaglandins Other Lipid Mediat. 2005. PMID: 15789622
Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.
Armer RE, Ashton MR, Boyd EA, Brennan CJ, Brookfield FA, Gazi L, Gyles SL, Hay PA, Hunter MG, Middlemiss D, Whittaker M, Xue L, Pettipher R. Armer RE, et al. Among authors: Xue L. J Med Chem. 2005 Oct 6;48(20):6174-7. doi: 10.1021/jm050519b. J Med Chem. 2005. PMID: 16190744
Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils.
Pettipher R, Vinall SL, Xue L, Speight G, Townsend ER, Gazi L, Whelan CJ, Armer RE, Payton MA, Hunter MG. Pettipher R, et al. Among authors: Xue L. J Pharmacol Exp Ther. 2012 Feb;340(2):473-82. doi: 10.1124/jpet.111.187203. Epub 2011 Nov 21. J Pharmacol Exp Ther. 2012. PMID: 22106101
A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants.
Gyles SL, Xue L, Townsend ER, Wettey F, Pettipher R. Gyles SL, et al. Among authors: Xue L. Immunology. 2006 Nov;119(3):362-8. doi: 10.1111/j.1365-2567.2006.02440.x. Immunology. 2006. PMID: 17067313 Free PMC article.
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