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Challenges for gene therapy of CNS disorders and implications for Parkinson's disease therapies.
Broadstock M, Yáñez-Muñoz RJ. Broadstock M, et al. Hum Gene Ther. 2012 Apr;23(4):340-3. doi: 10.1089/hum.2012.2507. Epub 2012 Apr 10. Hum Gene Ther. 2012. PMID: 22490128 No abstract available.
Efficient Expression of Igf-1 from Lentiviral Vectors Protects In Vitro but Does Not Mediate Behavioral Recovery of a Parkinsonian Lesion in Rats.
Lu-Nguyen NB, Broadstock M, Yáñez-Muñoz RJ. Lu-Nguyen NB, et al. Hum Gene Ther. 2015 Nov;26(11):719-33. doi: 10.1089/hum.2015.016. Epub 2015 Oct 1. Hum Gene Ther. 2015. PMID: 26222254 Free PMC article.
CAR-T in the clinic: drive with care.
Yáñez-Muñoz RJ, Grupp SA. Yáñez-Muñoz RJ, et al. Gene Ther. 2018 Jun;25(3):157-161. doi: 10.1038/s41434-018-0023-x. Epub 2018 Jul 1. Gene Ther. 2018. PMID: 29961080 No abstract available.
Nonintegrating Gene Therapy Vectors.
Athanasopoulos T, Munye MM, Yáñez-Muñoz RJ. Athanasopoulos T, et al. Among authors: yanez munoz rj. Hematol Oncol Clin North Am. 2017 Oct;31(5):753-770. doi: 10.1016/j.hoc.2017.06.007. Hematol Oncol Clin North Am. 2017. PMID: 28895845 Review.
Chimeric Trojan Protein Insertion in Lentiviral Membranes Makes Lentiviruses Susceptible to Neutralization by Anti-Tetanus Serum Antibodies.
Le Heron A, Patterson S, Yáñez-Muñoz RJ, Dickson G. Le Heron A, et al. Hum Gene Ther. 2017 Mar;28(3):242-254. doi: 10.1089/hum.2016.126. Epub 2016 Nov 26. Hum Gene Ther. 2017. PMID: 27889981
Gene correction of a duchenne muscular dystrophy mutation by meganuclease-enhanced exon knock-in.
Popplewell L, Koo T, Leclerc X, Duclert A, Mamchaoui K, Gouble A, Mouly V, Voit T, Pâques F, Cédrone F, Isman O, Yáñez-Muñoz RJ, Dickson G. Popplewell L, et al. Hum Gene Ther. 2013 Jul;24(7):692-701. doi: 10.1089/hum.2013.081. Hum Gene Ther. 2013. PMID: 23790397
Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury.
Bartus K, James ND, Didangelos A, Bosch KD, Verhaagen J, Yáñez-Muñoz RJ, Rogers JH, Schneider BL, Muir EM, Bradbury EJ. Bartus K, et al. J Neurosci. 2014 Apr 2;34(14):4822-36. doi: 10.1523/JNEUROSCI.4369-13.2014. J Neurosci. 2014. PMID: 24695702 Free PMC article.
Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat.
Yip PK, Wong LF, Sears TA, Yáñez-Muñoz RJ, McMahon SB. Yip PK, et al. PLoS Biol. 2010 Jun 22;8(6):e1000399. doi: 10.1371/journal.pbio.1000399. PLoS Biol. 2010. PMID: 20585375 Free PMC article.
Long-term episomal transgene expression from mitotically stable integration-deficient lentiviral vectors.
Kymäläinen H, Appelt JU, Giordano FA, Davies AF, Ogilvie CM, Ahmed SG, Laufs S, Schmidt M, Bode J, Yáñez-Muñoz RJ, Dickson G. Kymäläinen H, et al. Hum Gene Ther. 2014 May;25(5):428-42. doi: 10.1089/hum.2013.172. Epub 2014 Apr 10. Hum Gene Ther. 2014. PMID: 24483952 Free PMC article.
Lentiviral vector-mediated RNA silencing in the central nervous system.
Hutson TH, Foster E, Moon LD, Yáñez-Muñoz RJ. Hutson TH, et al. Hum Gene Ther Methods. 2014 Feb;25(1):14-32. doi: 10.1089/hgtb.2013.016. Epub 2013 Nov 1. Hum Gene Ther Methods. 2014. PMID: 24090197 Free PMC article. Review.
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