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2006 3
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Anti-inflammatory and anti-mutagenic effect of the YHK phytocompound in hepatocytes: in view of an age-management liver-protecting approach.
Catanzaro R, Celep G, Illuzzi N, Milazzo M, Rastmanesh R, Yaduvanshi SK, He F, Trushin M, Sapienza C, Srivastava N, Marotta F. Catanzaro R, et al. Rejuvenation Res. 2014 Apr;17(2):168-71. doi: 10.1089/rej.2013.1492. Epub 2014 Apr 8. Rejuvenation Res. 2014. PMID: 24050307 Free article.
Our study showed that YHK significantly reduced cellular growth in the HuH7 cell line (p<0.05). Moreover, this phytocompound partly reduced gene expression of NF-kappaB p65 (by 35%, p<0.05). These data suggest that YHK has a potential role as a modulator of RA …
Our study showed that YHK significantly reduced cellular growth in the HuH7 cell line (p<0.05). Moreover, this phytocompound partl …
Phytotherapeutic compound YHK exerts an inhibitory effect on early stage of experimentally-induced neoplastic liver lesions.
Marotta F, Harada M, Goh K, Lorenzetti A, Gelosa F, Minelli E. Marotta F, et al. Ann Hepatol. 2006 Oct-Dec;5(4):268-72. Ann Hepatol. 2006. PMID: 17151579 Free article.
The aim of this study was to investigate the effects of the herbal compound YHK on hepatocarcinogenesis induced by diethylntrosamine (DEN) in Sprague Dawley rats. ...Moreover, co-administration of YHK significantly reduced the incidence, number, size and volume of h …
The aim of this study was to investigate the effects of the herbal compound YHK on hepatocarcinogenesis induced by diethylntrosamine …
In vitro study on the mechanisms of action of a novel phytotherapeutic compound against human hepatoma cells.
Marotta F, Harada M, Goh KL, Lorenzetti A, Marandola P, Minelli E. Marotta F, et al. Ann Hepatol. 2007 Apr-Jun;6(2):111-6. Ann Hepatol. 2007. PMID: 17519835 Free article.

As compared to control, YHK-treated cultures showed a significant time-course decrease of the proliferation rate of HepG2 cell growth (p < 0.01). ...These data suggest that YHK seem to modulate the extrinsic and intrinsic regulators of apoptosis and sensitize tum

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As compared to control, YHK-treated cultures showed a significant time-course decrease of the proliferation rate of HepG2 cell growth …
Yo Jyo Hen Shi Ko (YHK) improves transaminases in nonalcoholic steatohepatitis (NASH): a randomized pilot study.
Chande N, Laidlaw M, Adams P, Marotta P. Chande N, et al. Dig Dis Sci. 2006 Jul;51(7):1183-9. doi: 10.1007/s10620-006-8030-y. Dig Dis Sci. 2006. PMID: 16944007 Clinical Trial.
In this controlled pilot study we found the novel nutraceutical agent YHK to be effective at reducing ALT values in patients with NASH. YHK is well tolerated. Further studies are justified to assess the impact of YHK in the natural history of NASH....
In this controlled pilot study we found the novel nutraceutical agent YHK to be effective at reducing ALT values in patients with NAS …
Liver exposure to xenobiotics: the aging factor and potentials for functional foods.
Marotta F, Lecroix P, Harada M, Masulair K, Safran P, Lorenzetti A, Ono-Nita SK, Marandola P. Marotta F, et al. Rejuvenation Res. 2006 Summer;9(2):338-41. doi: 10.1089/rej.2006.9.338. Rejuvenation Res. 2006. PMID: 16706665
Hepatocytes isolated from 20- and 4-month Wistar rats and cultured with or without alpha-linolenic acid (LNA) were then added with nutraceutical YHK or sylibin before the test with iron or copper. Overall, YHK proved to be more effective than sylibin in Fe/Cu-induce …
Hepatocytes isolated from 20- and 4-month Wistar rats and cultured with or without alpha-linolenic acid (LNA) were then added with nutraceut …