Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1991 4
1992 4
1993 24
1994 26
1995 41
1996 41
1997 40
1998 59
1999 51
2000 36
2001 59
2002 40
2003 45
2004 51
2005 54
2006 48
2007 81
2008 72
2009 70
2010 60
2011 87
2012 83
2013 97
2014 71
2015 89
2016 99
2017 109
2018 107
2019 127
2020 173
2021 180
2022 191
2023 198
2024 200
2025 223
2026 108

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

2,774 results

Results by year

Filters applied: . Clear all
Page 1
YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes.
Huang J, Wang X, Li N, Fan W, Li X, Zhou Q, Liu J, Li W, Zhang Z, Liu X, Zeng S, Yang H, Tian M, Yang P, Hou S. Huang J, et al. Adv Sci (Weinh). 2024 May;11(19):e2308031. doi: 10.1002/advs.202308031. Epub 2024 Mar 17. Adv Sci (Weinh). 2024. PMID: 38493498 Free PMC article.
In addition, p300 is identified as the writer of YY1 lactylation. Inhibition of p300 decreased YY1 lactylation and suppressed microglial inflammation in vivo and in vitro. ...Therapeutic effects can be achieved by targeting the lactate/p300/YY1 lactylation/in …
In addition, p300 is identified as the writer of YY1 lactylation. Inhibition of p300 decreased YY1 lactylation and suppressed …
YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6.
Chen S, Lu K, Hou Y, You Z, Shu C, Wei X, Wu T, Shi N, Zhang G, Wu J, Chen S, Zhang L, Li W, Zhang D, Ju S, Chen M, Xu B. Chen S, et al. J Immunother Cancer. 2023 Apr;11(4):e006020. doi: 10.1136/jitc-2022-006020. J Immunother Cancer. 2023. PMID: 37094986 Free PMC article.
METHODS: Tissue microarray consisting of prostate cancer (PCa), normal prostate, and lymph node metastatic samples from patients with PCa were stained with Yin Yang 1 (YY1) and CD163. Transgenic mice overexpressing YY1 were constructed to observe PCa tumorigenesis. …
METHODS: Tissue microarray consisting of prostate cancer (PCa), normal prostate, and lymph node metastatic samples from patients with PCa we …
YY1 Is a Structural Regulator of Enhancer-Promoter Loops.
Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA. Weintraub AS, et al. Cell. 2017 Dec 14;171(7):1573-1588.e28. doi: 10.1016/j.cell.2017.11.008. Epub 2017 Dec 7. Cell. 2017. PMID: 29224777 Free PMC article.
Deletion of YY1 binding sites or depletion of YY1 protein disrupts enhancer-promoter looping and gene expression. We propose that YY1-mediated enhancer-promoter interactions are a general feature of mammalian gene control....
Deletion of YY1 binding sites or depletion of YY1 protein disrupts enhancer-promoter looping and gene expression. We propose t …
Crosstalk between YY1 and lncRNAs in cancer: A review.
Wang XL, Li J, Cao YH. Wang XL, et al. Medicine (Baltimore). 2022 Dec 9;101(49):e31990. doi: 10.1097/MD.0000000000031990. Medicine (Baltimore). 2022. PMID: 36626426 Free PMC article. Review.
These effects lead to upregulation of YY1 associated with poor outcomes in many tumors. Growing research evidence suggests that long non-coding RNAs (lncRNAs) play important roles in the regulatory network of YY1. YY1 can regulate lncRNA, and serve as the reg …
These effects lead to upregulation of YY1 associated with poor outcomes in many tumors. Growing research evidence suggests that long …
Multifunctional YY1 in Liver Diseases.
Zhang M, Zhang Y, Yang S, Zhou J, Gao W, Yang X, Yang D, Tian Z, Wu Y, Ni B. Zhang M, et al. Semin Liver Dis. 2017 Nov;37(4):363-376. doi: 10.1055/s-0037-1607451. Epub 2017 Dec 22. Semin Liver Dis. 2017. PMID: 29272897 Review.
The transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression, depending on the cellular context. ...In this review, we will summarize the current knowledge on YY1 in liver diseases, providing a focused discussio …
The transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression, depending on the …
YY1 Is an Inducer of Cancer Metastasis.
Wang W, Li D, Sui G. Wang W, et al. Crit Rev Oncog. 2017;22(1-2):1-11. doi: 10.1615/CritRevOncog.2017021314. Crit Rev Oncog. 2017. PMID: 29604932 Review.
To date, ample evidence suggests a critical regulatory role of YY1 in tumor cell metastasis. The potential of YY1 as a valuable biomarker for cancer metastasis has been increasingly known. ...Finally, we discuss the correlation between YY1 expression and clin …
To date, ample evidence suggests a critical regulatory role of YY1 in tumor cell metastasis. The potential of YY1 as a valuabl …
YY1: Master regulator of metabolic reprogramming in cancer.
Akram R, Hosea R, Zhao F, Górecki A, Figiel M, Wu S, Kasim V. Akram R, et al. Biochim Biophys Acta Rev Cancer. 2026 Feb;1881(1):189505. doi: 10.1016/j.bbcan.2025.189505. Epub 2025 Dec 5. Biochim Biophys Acta Rev Cancer. 2026. PMID: 41354327 Review.
Mechanistically, YY1 enhances aerobic glycolysis by diverting glycolytic flux toward lactate production. ...Collectively, these findings highlight the equilibrium between YY1 and its paralog YY2 in sustaining redox homeostasis and tumor progression while positioning …
Mechanistically, YY1 enhances aerobic glycolysis by diverting glycolytic flux toward lactate production. ...Collectively, these findi …
Therapeutic Implications of Targeting YY1 in Glioblastoma.
Navasardyan I, Zaravinos A, Bonavida B. Navasardyan I, et al. Cancers (Basel). 2024 May 30;16(11):2074. doi: 10.3390/cancers16112074. Cancers (Basel). 2024. PMID: 38893192 Free PMC article. Review.
The transcription factor Yin Yang 1 (YY1) plays a pivotal role in the pathogenesis of glioblastoma multiforme (GBM), an aggressive form of brain tumor. ...Different therapeutic implications targeting YY1 in GBM and its inherent associated challenges encompass the us …
The transcription factor Yin Yang 1 (YY1) plays a pivotal role in the pathogenesis of glioblastoma multiforme (GBM), an aggressive fo …
YY1-controlled regulatory connectivity and transcription are influenced by the cell cycle.
Lam JC, Aboreden NG, Midla SC, Wang S, Huang A, Keller CA, Giardine B, Henderson KA, Hardison RC, Zhang H, Blobel GA. Lam JC, et al. Nat Genet. 2024 Sep;56(9):1938-1952. doi: 10.1038/s41588-024-01871-y. Epub 2024 Aug 29. Nat Genet. 2024. PMID: 39210046 Free PMC article.
Despite its reported ability to interact with cohesin, the formation of YY1-dependent enhancer-promoter loops does not involve stalling of cohesin-mediated loop extrusion. ...YY1 degradation during the mitosis-to-G1-phase interval revealed a set of enhancer-promoter …
Despite its reported ability to interact with cohesin, the formation of YY1-dependent enhancer-promoter loops does not involve stalli …
The roles of YY1 in reproductive system: an overview.
Wang Y, He S, Huang Q, Yang J, Yang C, Ding J. Wang Y, et al. Chem Biol Interact. 2025 Aug 25;417:111560. doi: 10.1016/j.cbi.2025.111560. Epub 2025 May 15. Chem Biol Interact. 2025. PMID: 40381670 Review.
In recent years, the discovery of the functional activity of YY1 in the reproductive tissues of animals, including humans has attracted more and more attention. YY1 plays important roles in the development of follicular, embryo and placenta, as well as spermatogenes …
In recent years, the discovery of the functional activity of YY1 in the reproductive tissues of animals, including humans has attract …
2,774 results