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Nicotine breaks down preformed Alzheimer's beta-amyloid fibrils in vitro.
Ono K, Hasegawa K, Yamada M, Naiki H. Ono K, et al. Biol Psychiatry. 2002 Nov 1;52(9):880-6. doi: 10.1016/s0006-3223(02)01417-8. Biol Psychiatry. 2002. PMID: 12399141
Kinetic modeling and determination of reaction constants of Alzheimer's beta-amyloid fibril extension and dissociation using surface plasmon resonance.
Hasegawa K, Ono K, Yamada M, Naiki H. Hasegawa K, et al. Biochemistry. 2002 Nov 19;41(46):13489-98. doi: 10.1021/bi020369w. Biochemistry. 2002. PMID: 12427009
On the basis of this model, the critical monomer concentration ([M](e)) and the equilibrium association constant (K) were calculated, for the first time, to be 20 nM and 5 x 10(7) M(-1), respectively. Alternatively, [M](e) was directly measured as 200 nM, whi …
On the basis of this model, the critical monomer concentration ([M](e)) and the equilibrium association constant (K) were calculated, …
Risk factors for cerebral amyloid angiopathy in the elderly.
Yamada M. Yamada M. Ann N Y Acad Sci. 2002 Nov;977:37-44. doi: 10.1111/j.1749-6632.2002.tb04797.x. Ann N Y Acad Sci. 2002. PMID: 12480732
Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease.
Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M. Ono K, et al. J Neurochem. 2003 Oct;87(1):172-81. doi: 10.1046/j.1471-4159.2003.01976.x. J Neurochem. 2003. PMID: 12969264
The effective concentrations (EC50) of myricetin, morin and quercetin for the formation, extension and destabilization of fAbetas were in the order of 0.1-1 micro m. ...
The effective concentrations (EC50) of myricetin, morin and quercetin for the formation, extension and destabilization of fAbetas were in th …
[Cerebral amyloid angiopathy].
Yamada M. Yamada M. Nihon Rinsho. 2004 Apr;62 Suppl 4:167-73. Nihon Rinsho. 2004. PMID: 15174665 Japanese. No abstract available.
Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro.
Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M. Ono K, et al. Exp Neurol. 2004 Oct;189(2):380-92. doi: 10.1016/j.expneurol.2004.05.035. Exp Neurol. 2004. PMID: 15380488
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