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Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity.
Ishigaki Y, Katagiri H, Yamada T, Ogihara T, Imai J, Uno K, Hasegawa Y, Gao J, Ishihara H, Shimosegawa T, Sakoda H, Asano T, Oka Y. Ishigaki Y, et al. Diabetes. 2005 Feb;54(2):322-32. doi: 10.2337/diabetes.54.2.322. Diabetes. 2005. PMID: 15677488
Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: neuronal involvement in food-intake regulation.
Yamada T, Katagiri H, Ishigaki Y, Ogihara T, Imai J, Uno K, Hasegawa Y, Gao J, Ishihara H, Niijima A, Mano H, Aburatani H, Asano T, Oka Y. Yamada T, et al. Cell Metab. 2006 Mar;3(3):223-9. doi: 10.1016/j.cmet.2006.02.001. Cell Metab. 2006. PMID: 16517409
Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.
Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y. Uno K, et al. Science. 2006 Jun 16;312(5780):1656-9. doi: 10.1126/science.1126010. Science. 2006. PMID: 16778057
Cold exposure suppresses serum adiponectin levels through sympathetic nerve activation in mice.
Imai J, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Uno K, Hasegawa Y, Gao J, Ishihara H, Sasano H, Oka Y. Imai J, et al. Obesity (Silver Spring). 2006 Jul;14(7):1132-41. doi: 10.1038/oby.2006.130. Obesity (Silver Spring). 2006. PMID: 16899794
Involvement of apolipoprotein E in excess fat accumulation and insulin resistance.
Gao J, Katagiri H, Ishigaki Y, Yamada T, Ogihara T, Imai J, Uno K, Hasegawa Y, Kanzaki M, Yamamoto TT, Ishibashi S, Oka Y. Gao J, et al. Diabetes. 2007 Jan;56(1):24-33. doi: 10.2337/db06-0144. Diabetes. 2007. PMID: 17192461
Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice.
Yoshizumi S, Suzuki S, Hirai M, Hinokio Y, Yamada T, Yamada T, Tsunoda U, Aburatani H, Yamaguchi K, Miyagi T, Oka Y. Yoshizumi S, et al. Metabolism. 2007 Mar;56(3):420-9. doi: 10.1016/j.metabol.2006.10.027. Metabolism. 2007. PMID: 17292733
Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis.
Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Uno K, Hasegawa Y, Kaneko K, Ogihara T, Ishihara H, Sato Y, Takikawa K, Nishimichi N, Matsuda H, Sawamura T, Oka Y. Ishigaki Y, et al. Circulation. 2008 Jul 1;118(1):75-83. doi: 10.1161/CIRCULATIONAHA.107.745174. Epub 2008 Jun 16. Circulation. 2008. PMID: 18559699
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