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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M. Komatsu M, et al. Among authors: yamamoto m. Nat Cell Biol. 2010 Mar;12(3):213-23. doi: 10.1038/ncb2021. Epub 2010 Feb 21. Nat Cell Biol. 2010. PMID: 20173742
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P. Wakabayashi N, et al. Among authors: yamamoto m. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5. doi: 10.1073/pnas.0307301101. Epub 2004 Feb 5. Proc Natl Acad Sci U S A. 2004. PMID: 14764894 Free PMC article.
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