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Statistical moments in pharmacokinetics.
Yamaoka K, Nakagawa T, Uno T. Yamaoka K, et al. J Pharmacokinet Biopharm. 1978 Dec;6(6):547-58. doi: 10.1007/BF01062109. J Pharmacokinet Biopharm. 1978. PMID: 731417
Effect of liver intoxication by carbon tetrachloride on hepatic local disposition of oxacillin using moment characteristics as index.
Yasui H, Yamaoka K, Fukuyama T, Nakagawa T. Yasui H, et al. Drug Metab Dispos. 1995 Aug;23(8):779-85. Drug Metab Dispos. 1995. PMID: 7493542
In the relationship between the dispersion model and moments, it was shown that the blood space VB increased from 15 to 20%, the index for distribution (1 + k') of oxacillin from 1.0 to 1.5, the efficiency number RN of oxacillin decreased from 0.7 to 0.3 with the increase …
In the relationship between the dispersion model and moments, it was shown that the blood space VB increased from 15 to 20%, the index for d …
Synthetic ciguatoxins selectively activate Nav1.8-derived chimeric sodium channels expressed in HEK293 cells.
Yamaoka K, Inoue M, Miyazaki K, Hirama M, Kondo C, Kinoshita E, Miyoshi H, Seyama I. Yamaoka K, et al. J Biol Chem. 2009 Mar 20;284(12):7597-605. doi: 10.1074/jbc.M806481200. Epub 2009 Jan 21. J Biol Chem. 2009. PMID: 19164297 Free PMC article.
The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Na(v)1.2, Na(v)1.4, and Na(v)1.5) by accelerating activation kinetics and shifting the activation curve toward hyperpolarization (Yamaoka, K., Inoue, M., Miyahara …
The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Na(v)1.2, Na(v)1.4, and Na(v)1.5) by …
A quantitative and comparative study of the effects of a synthetic ciguatoxin CTX3C on the kinetic properties of voltage-dependent sodium channels.
Yamaoka K, Inoue M, Miyahara H, Miyazaki K, Hirama M. Yamaoka K, et al. Br J Pharmacol. 2004 Jul;142(5):879-89. doi: 10.1038/sj.bjp.0705852. Epub 2004 Jun 14. Br J Pharmacol. 2004. PMID: 15197105 Free PMC article.
The toxin (1.0 micromol l(-1)) shifted the activation potential (V(1/2) of activation curve) in the negative direction by 4-9 mV and increased the slope factor (k) from 8 mV to between 9 and 12 mV (indicative of decreased steepness of the activation curve), thereby resulti …
The toxin (1.0 micromol l(-1)) shifted the activation potential (V(1/2) of activation curve) in the negative direction by 4-9 mV and increas …
Structural determinants for the action of grayanotoxin in D1 S4-S5 and D4 S4-S5 intracellular linkers of sodium channel alpha-subunits.
Maejima H, Kinoshita E, Yuki T, Yakehiro M, Seyama I, Yamaoka K. Maejima H, et al. Biochem Biophys Res Commun. 2002 Jul 12;295(2):452-7. doi: 10.1016/s0006-291x(02)00702-7. Biochem Biophys Res Commun. 2002. PMID: 12150970
Synthesis of skeletal analogues of saxitoxin derivatives and evaluation of their inhibitory activity on sodium ion channels Na(V)1.4 and Na(V)1.5.
Shinohara R, Akimoto T, Iwamoto O, Hirokawa T, Yotsu-Yamashita M, Yamaoka K, Nagasawa K. Shinohara R, et al. Chemistry. 2011 Oct 17;17(43):12144-52. doi: 10.1002/chem.201101058. Epub 2011 Sep 16. Chemistry. 2011. PMID: 21922571
Novel wasp toxin discriminates between neuronal and cardiac sodium channels.
Kinoshita E, Maejima H, Yamaoka K, Konno K, Kawai N, Shimizu E, Yokote S, Nakayama H, Seyama I. Kinoshita E, et al. Mol Pharmacol. 2001 Jun;59(6):1457-63. Mol Pharmacol. 2001. PMID: 11353806
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