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First total synthesis of (+/-)-Linderol A, a tricyclic hexahydrodibenzofuran constituent of Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells.
Yamashita M, Ohta N, Shimizu T, Matsumoto K, Matsuura Y, Kawasaki I, Tanaka T, Maezaki N, Ohta S. Yamashita M, et al. J Org Chem. 2003 Feb 21;68(4):1216-24. doi: 10.1021/jo020619e. J Org Chem. 2003. PMID: 12585858
Studies on interactions between functional foods or dietary supplements and medicines. I. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of diltiazem in rats.
Ohnishi N, Kusuhara M, Yoshioka M, Kuroda K, Soga A, Nishikawa F, Koishi T, Nakagawa M, Hori S, Matsumoto T, Yamashita M, Ohta S, Takara K, Yokoyama T. Ohnishi N, et al. Biol Pharm Bull. 2003 Sep;26(9):1315-20. doi: 10.1248/bpb.26.1315. Biol Pharm Bull. 2003. PMID: 12951478
Novel stereoconvergent transformation of 1,2a-disubstituted 1,2,2a,8b-tetrahydro-3H-benzo[b]cyclobuta[d]pyran-3-ones to 1,3-disubstituted 1,2,4a,9b-tetrahydrodibenzofuran-4-ols and its application to the second-generation synthesis of (+/-)-linderol A.
Yamashita M, Inaba T, Nagahama M, Shimizu T, Kosaka S, Kawasaki I, Ohta S. Yamashita M, et al. Org Biomol Chem. 2005 Jun 21;3(12):2296-304. doi: 10.1039/b503890a. Epub 2005 May 11. Org Biomol Chem. 2005. PMID: 16010364
Asymmetric total synthesis of (-)-Linderol A.
Yamashita M, Yadav ND, Sawaki T, Takao I, Kawasaki I, Sugimoto Y, Miyatake A, Murai K, Takahara A, Kurume A, Ohta S. Yamashita M, et al. J Org Chem. 2007 Jul 20;72(15):5697-703. doi: 10.1021/jo070682+. Epub 2007 Jun 19. J Org Chem. 2007. PMID: 17579456
Synthesis of (±)-8-deisopropyladunctin B.
Nomura S, Arimitsu K, Yamaguchi S, Kosuga Y, Kakimoto Y, Komai T, Hasegawa K, Nakanishi A, Miyoshi T, Iwasaki H, Ozeki M, Kawasaki I, Kurume A, Ohta S, Yamashita M. Nomura S, et al. Chem Pharm Bull (Tokyo). 2012;60(1):94-103. doi: 10.1248/cpb.60.94. Chem Pharm Bull (Tokyo). 2012. PMID: 22223380
Preparation of benzo[b]furans having five-membered heterocycles at the 2-position and 2-(4-Alkylcarbamoylbuta-1,3-dienyl)benzo[b]furans, and their cysteinyl leukotriene receptor (cysLT1, cysLT2) inhibitory activity.
Akai Y, Tabuchi Y, Ando K, Ito A, Sakata Y, Kawasaki I, Ohishi T, Yamashita M, Ohta S, Nishide K, Ohishi Y. Akai Y, et al. Chem Pharm Bull (Tokyo). 2012;60(11):1461-7. doi: 10.1248/cpb.c12-00560. Chem Pharm Bull (Tokyo). 2012. PMID: 23124570
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