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Selective cyclooxygenase-2 inhibitors show a differential ability to inhibit proliferation and induce apoptosis of colon adenocarcinoma cells.
Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S. Yamazaki R, et al. FEBS Lett. 2002 Nov 6;531(2):278-84. doi: 10.1016/s0014-5793(02)03535-4. FEBS Lett. 2002. PMID: 12417326
Nonsteroidal anti-inflammatory drugs induce apoptosis in association with activation of peroxisome proliferator-activated receptor gamma in rheumatoid synovial cells.
Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S. Yamazaki R, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):18-25. doi: 10.1124/jpet.302.1.18. J Pharmacol Exp Ther. 2002. PMID: 12065695
Furthermore, the ability of NSAIDs and PPARgamma ligands to stimulate the activation of PPARgamma correlated with their ability to decrease cell viability(r = 0.92, p < 0.01) and ability to induce DNA fragmentation (r = 0.97, p < 0.001) in synovial cells. ...
Furthermore, the ability of NSAIDs and PPARgamma ligands to stimulate the activation of PPARgamma correlated with their ability to decrease …
Induction of apoptosis in rheumatoid synovial fibroblasts by celecoxib, but not by other selective cyclooxygenase 2 inhibitors.
Kusunoki N, Yamazaki R, Kawai S. Kusunoki N, et al. Among authors: yamazaki r. Arthritis Rheum. 2002 Dec;46(12):3159-67. doi: 10.1002/art.10692. Arthritis Rheum. 2002. PMID: 12483719
Aspirin and sodium salicylate inhibit proliferation and induce apoptosis in rheumatoid synovial cells.
Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S. Yamazaki R, et al. J Pharm Pharmacol. 2002 Dec;54(12):1675-9. doi: 10.1211/002235702261. J Pharm Pharmacol. 2002. PMID: 12542898
Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts.
Kusunoki N, Yamazaki R, Kitasato H, Beppu M, Aoki H, Kawai S. Kusunoki N, et al. Among authors: yamazaki r. BMC Pharmacol. 2004 Feb 17;4:2. doi: 10.1186/1471-2210-4-2. BMC Pharmacol. 2004. PMID: 15040811 Free PMC article.
Pro-apoptotic effect of nonsteroidal anti-inflammatory drugs on synovial fibroblasts.
Kusunoki N, Yamazaki R, Kawai S. Kusunoki N, et al. Among authors: yamazaki r. Mod Rheumatol. 2008;18(6):542-51. doi: 10.1007/s10165-008-0102-8. Epub 2008 Jul 19. Mod Rheumatol. 2008. PMID: 18642053 Review.
G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell.
Tahara E Jr, Tahara H, Kanno M, Naka K, Takeda Y, Matsuzaki T, Yamazaki R, Ishihara H, Yasui W, Barrett JC, Ide T, Tahara E. Tahara E Jr, et al. Among authors: yamazaki r. Cancer Immunol Immunother. 2005 Aug;54(8):729-40. doi: 10.1007/s00262-004-0645-2. Epub 2005 Feb 1. Cancer Immunol Immunother. 2005. PMID: 15685448
YPC-21661 and YPC-22026, novel small molecules, inhibit ZNF143 activity in vitro and in vivo.
Haibara H, Yamazaki R, Nishiyama Y, Ono M, Kobayashi T, Hokkyo-Itagaki A, Nishisaka F, Nishiyama H, Kurita A, Matsuzaki T, Izumi H, Kohno K. Haibara H, et al. Among authors: yamazaki r. Cancer Sci. 2017 May;108(5):1042-1048. doi: 10.1111/cas.13199. Epub 2017 Apr 24. Cancer Sci. 2017. PMID: 28192620 Free PMC article.
Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes.
Izumi H, Wakasugi T, Shimajiri S, Tanimoto A, Sasaguri Y, Kashiwagi E, Yasuniwa Y, Akiyama M, Han B, Wu Y, Uchiumi T, Arao T, Nishio K, Yamazaki R, Kohno K. Izumi H, et al. Among authors: yamazaki r. Cancer Sci. 2010 Dec;101(12):2538-45. doi: 10.1111/j.1349-7006.2010.01725.x. Epub 2010 Sep 23. Cancer Sci. 2010. PMID: 20860770
Synthesis of phenanthroindolizidine alkaloids and evaluation of their antitumor activities and toxicities.
Ikeda T, Yaegashi T, Matsuzaki T, Yamazaki R, Hashimoto S, Sawada S. Ikeda T, et al. Among authors: yamazaki r. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5978-81. doi: 10.1016/j.bmcl.2011.07.120. Epub 2011 Aug 6. Bioorg Med Chem Lett. 2011. PMID: 21865039
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