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The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3.
Zhou Y, He C, Yan D, Liu F, Liu H, Chen J, Cao T, Zuo M, Wang P, Ge Y, Lu H, Tong Q, Qin C, Deng Y, Ge B. Zhou Y, et al. Nat Immunol. 2016 Apr;17(4):397-405. doi: 10.1038/ni.3395. Epub 2016 Feb 29. Nat Immunol. 2016. PMID: 26928339
Modulation of host signaling in the inflammatory response by enteropathogenic Escherichia coli virulence proteins.
Zhuang X, Chen Z, He C, Wang L, Zhou R, Yan D, Ge B. Zhuang X, et al. Cell Mol Immunol. 2017 Mar;14(3):237-244. doi: 10.1038/cmi.2016.52. Epub 2016 Oct 31. Cell Mol Immunol. 2017. PMID: 27796284 Free PMC article. Review.
Posttranslational Modification Control of Inflammatory Signaling.
Si Y, Zhang Y, Chen Z, Zhou R, Zhang Y, Hao D, Yan D. Si Y, et al. Adv Exp Med Biol. 2017;1024:37-61. doi: 10.1007/978-981-10-5987-2_2. Adv Exp Med Biol. 2017. PMID: 28921464
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SHE, Chen C, Mao Z, Ge B. Liu H, et al. Nature. 2018 Nov;563(7729):131-136. doi: 10.1038/s41586-018-0629-6. Epub 2018 Oct 24. Nature. 2018. PMID: 30356214
PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1.
Wang L, Zhou Y, Chen Z, Sun L, Wu J, Li H, Liu F, Wang F, Yang C, Yang J, Leng Q, Zhang Q, Xu A, Shen L, Sun J, Wu D, Fang C, Lu H, Yan D, Ge B. Wang L, et al. Nat Commun. 2019 Feb 14;10(1):746. doi: 10.1038/s41467-019-08524-3. Nat Commun. 2019. PMID: 30765691 Free PMC article.
β-arrestin 2 quenches TLR signaling to facilitate the immune evasion of EPEC.
Chen Z, Zhou R, Zhang Y, Hao D, Wang Y, Huang S, Liu N, Xia C, Yissachar N, Huang F, Chu Y, Yan D. Chen Z, et al. Gut Microbes. 2020 Sep 2;11(5):1423-1437. doi: 10.1080/19490976.2020.1759490. Epub 2020 May 13. Gut Microbes. 2020. PMID: 32403971
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