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Drug targeting of the c-MYC promoter to repress gene expression via a G-quadruplex silencer element.
Hurley LH, Von Hoff DD, Siddiqui-Jain A, Yang D. Hurley LH, et al. Among authors: yang d. Semin Oncol. 2006 Aug;33(4):498-512. doi: 10.1053/j.seminoncol.2006.04.012. Semin Oncol. 2006. PMID: 16890804 Review.
Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug.
Dai J, Punchihewa C, Mistry P, Ooi AT, Yang D. Dai J, et al. Among authors: yang d. J Biol Chem. 2004 Oct 29;279(44):46096-103. doi: 10.1074/jbc.M404053200. Epub 2004 Aug 17. J Biol Chem. 2004. PMID: 15317822
Here we present the first NMR structure of MLN944 complexed with d(ATGCAT)(2) DNA duplex, demonstrating a novel binding mode in which the two phenazine rings bis-intercalate at the 5'-TpG site, with the carboxamide amino linker lying in the major groove of DNA. ...
Here we present the first NMR structure of MLN944 complexed with d(ATGCAT)(2) DNA duplex, demonstrating a novel binding mode in which …
Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization.
Ambrus A, Chen D, Dai J, Jones RA, Yang D. Ambrus A, et al. Among authors: yang d. Biochemistry. 2005 Feb 15;44(6):2048-58. doi: 10.1021/bi048242p. Biochemistry. 2005. PMID: 15697230
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry protocol for monitoring the progress of enzymatic (13)C/(15)N-labeled DNA syntheses.
Ambrus A, Chen D, Whatcott C, Somogyi A, Yang D. Ambrus A, et al. Among authors: yang d. Anal Biochem. 2005 Jul 15;342(2):246-53. doi: 10.1016/j.ab.2005.04.008. Anal Biochem. 2005. PMID: 15989927
An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution.
Dai J, Dexheimer TS, Chen D, Carver M, Ambrus A, Jones RA, Yang D. Dai J, et al. Among authors: yang d. J Am Chem Soc. 2006 Feb 1;128(4):1096-8. doi: 10.1021/ja055636a. J Am Chem Soc. 2006. PMID: 16433524 Free PMC article.
Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution.
Ambrus A, Chen D, Dai J, Bialis T, Jones RA, Yang D. Ambrus A, et al. Among authors: yang d. Nucleic Acids Res. 2006 May 19;34(9):2723-35. doi: 10.1093/nar/gkl348. Print 2006. Nucleic Acids Res. 2006. PMID: 16714449 Free PMC article.
Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). The formation and stabilization of DNA G-quadruplexes in the human telomeric sequence have been shown to inhibit the activity of telomerase, thus the telomeric DNA G-quadruplex has been considered as …
Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). The formation and stabilization of DNA G-quadruplexes in th …
Structure of the biologically relevant G-quadruplex in the c-MYC promoter.
Yang D, Hurley LH. Yang D, et al. Nucleosides Nucleotides Nucleic Acids. 2006;25(8):951-68. doi: 10.1080/15257770600809913. Nucleosides Nucleotides Nucleic Acids. 2006. PMID: 16901825 Review.
NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region.
Dai J, Chen D, Jones RA, Hurley LH, Yang D. Dai J, et al. Among authors: yang d. Nucleic Acids Res. 2006;34(18):5133-44. doi: 10.1093/nar/gkl610. Epub 2006 Sep 22. Nucleic Acids Res. 2006. PMID: 16998187 Free PMC article.
XR5944: A potent inhibitor of estrogen receptors.
Punchihewa C, De Alba A, Sidell N, Yang D. Punchihewa C, et al. Among authors: yang d. Mol Cancer Ther. 2007 Jan;6(1):213-9. doi: 10.1158/1535-7163.MCT-06-0392. Epub 2007 Jan 11. Mol Cancer Ther. 2007. PMID: 17218634
In contrast, the RNA polymerase inhibitor actinomycin D inhibits the transcription from both the above-mentioned promoters. The specificity of XR5944 activity is displayed by a separate reporter assay in which the transactivation of reporter gene expression by Sp1 proteins …
In contrast, the RNA polymerase inhibitor actinomycin D inhibits the transcription from both the above-mentioned promoters. The speci …
Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation.
Dai J, Punchihewa C, Ambrus A, Chen D, Jones RA, Yang D. Dai J, et al. Among authors: yang d. Nucleic Acids Res. 2007;35(7):2440-50. doi: 10.1093/nar/gkm009. Epub 2007 Mar 29. Nucleic Acids Res. 2007. PMID: 17395643 Free PMC article.
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