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Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells.
Sun J, Li ZM, Hu ZY, Zeng ZL, Yang DJ, Jiang WQ. Sun J, et al. Among authors: yang dj. Oncol Rep. 2009 Jul;22(1):193-8. doi: 10.3892/or_00000424. Oncol Rep. 2009. PMID: 19513523
Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells.
Zhang M, Liu H, Guo R, Ling Y, Wu X, Li B, Roller PP, Wang S, Yang D. Zhang M, et al. Among authors: yang d. Biochem Pharmacol. 2003 Jul 1;66(1):93-103. doi: 10.1016/s0006-2952(03)00248-x. Biochem Pharmacol. 2003. PMID: 12818369
A small molecule compound inhibits AKT pathway in ovarian cancer cell lines.
Tang HJ, Jin X, Wang S, Yang D, Cao Y, Chen J, Gossett DR, Lin J. Tang HJ, et al. Among authors: yang d. Gynecol Oncol. 2006 Feb;100(2):308-17. doi: 10.1016/j.ygyno.2005.08.044. Epub 2005 Oct 4. Gynecol Oncol. 2006. PMID: 16209885
p27 degradation by an ellipticinium series of compound via ubiquitin-proteasome pathway.
Pamarthy D, Tan M, Wu M, Chen J, Yang D, Wang S, Zhang H, Sun Y. Pamarthy D, et al. Among authors: yang d. Cancer Biol Ther. 2007 Mar;6(3):360-6. doi: 10.4161/cbt.6.3.3703. Epub 2007 Mar 12. Cancer Biol Ther. 2007. PMID: 17312389
Synergistic cytotoxicity of Bcl-xL inhibitor, gossypol and chemotherapeutic agents in non-Hodgkin's lymphoma cells.
Li ZM, Jiang WQ, Zhu ZY, Zhu XF, Zhou JM, Liu ZC, Yang DJ, Guang ZZ. Li ZM, et al. Among authors: yang dj. Cancer Biol Ther. 2008 Jan;7(1):51-60. doi: 10.4161/cbt.7.1.5128. Epub 2007 Oct 8. Cancer Biol Ther. 2008. PMID: 17938578
Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model.
Arnold AA, Aboukameel A, Chen J, Yang D, Wang S, Al-Katib A, Mohammad RM. Arnold AA, et al. Among authors: yang d. Mol Cancer. 2008 Feb 14;7:20. doi: 10.1186/1476-4598-7-20. Mol Cancer. 2008. PMID: 18275607 Free PMC article.
ApoG2, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces apoptosis and suppresses tumor growth in nasopharyngeal carcinoma xenografts.
Hu ZY, Zhu XF, Zhong ZD, Sun J, Wang J, Yang D, Zeng YX. Hu ZY, et al. Among authors: yang d. Int J Cancer. 2008 Nov 15;123(10):2418-29. doi: 10.1002/ijc.23752. Int J Cancer. 2008. PMID: 18712728
Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo.
Sun Y, Wu J, Aboukameel A, Banerjee S, Arnold AA, Chen J, Nikolovska-Coleska Z, Lin Y, Ling X, Yang D, Wang S, Al-Katib A, Mohammad RM. Sun Y, et al. Among authors: yang d. Cancer Biol Ther. 2008 Sep;7(9):1418-26. doi: 10.4161/cbt.7.9.6430. Epub 2008 Sep 4. Cancer Biol Ther. 2008. PMID: 18769131 Free PMC article.
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