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Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion.
Yang HS, Matthews CP, Clair T, Wang Q, Baker AR, Li CC, Tan TH, Colburn NH. Yang HS, et al. Mol Cell Biol. 2006 Feb;26(4):1297-306. doi: 10.1128/MCB.26.4.1297-1306.2006. Mol Cell Biol. 2006. PMID: 16449643 Free PMC article.
Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI.
Zakowicz H, Yang HS, Stark C, Wlodawer A, Laronde-Leblanc N, Colburn NH. Zakowicz H, et al. RNA. 2005 Mar;11(3):261-74. doi: 10.1261/rna.7191905. Epub 2005 Jan 20. RNA. 2005. PMID: 15661843 Free PMC article.
A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A.
Yang HS, Cho MH, Zakowicz H, Hegamyer G, Sonenberg N, Colburn NH. Yang HS, et al. Mol Cell Biol. 2004 May;24(9):3894-906. doi: 10.1128/mcb.24.9.3894-3906.2004. Mol Cell Biol. 2004. PMID: 15082783 Free PMC article.
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation.
Yang HS, Jansen AP, Komar AA, Zheng X, Merrick WC, Costes S, Lockett SJ, Sonenberg N, Colburn NH. Yang HS, et al. Mol Cell Biol. 2003 Jan;23(1):26-37. doi: 10.1128/mcb.23.1.26-37.2003. Mol Cell Biol. 2003. PMID: 12482958 Free PMC article.
Promising molecular targets for cancer prevention: AP-1, NF-kappa B and Pdcd4.
Young MR, Yang HS, Colburn NH. Young MR, et al. Trends Mol Med. 2003 Jan;9(1):36-41. doi: 10.1016/s1471-4914(02)00009-6. Trends Mol Med. 2003. PMID: 12524209 Review.
Structural basis for translational inhibition by the tumour suppressor Pdcd4.
Loh PG, Yang HS, Walsh MA, Wang Q, Wang X, Cheng Z, Liu D, Song H. Loh PG, et al. EMBO J. 2009 Feb 4;28(3):274-85. doi: 10.1038/emboj.2008.278. Epub 2009 Jan 15. EMBO J. 2009. PMID: 19153607 Free PMC article.
Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells.
Dey S, Bakthavatchalu V, Tseng MT, Wu P, Florence RL, Grulke EA, Yokel RA, Dhar SK, Yang HS, Chen Y, St Clair DK. Dey S, et al. Carcinogenesis. 2008 Oct;29(10):1920-9. doi: 10.1093/carcin/bgn175. Epub 2008 Aug 1. Carcinogenesis. 2008. PMID: 18676681 Free PMC article.
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