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Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.
Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK. Xiao S, et al. Among authors: yang j. Immunity. 2014 Apr 17;40(4):477-89. doi: 10.1016/j.immuni.2014.04.004. Immunity. 2014. PMID: 24745332 Free PMC article.
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM. Watanabe N, et al. Among authors: yang j. Nat Immunol. 2003 Jul;4(7):670-9. doi: 10.1038/ni944. Epub 2003 Jun 8. Nat Immunol. 2003. PMID: 12796776
Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t.
Yang J, Yang M, Htut TM, Ouyang X, Hanidu A, Li X, Sellati R, Jiang H, Zhang S, Li H, Zhao J, Ting AT, Mayer L, Unkeless JC, Labadia ME, Hodge M, Li J, Xiong H. Yang J, et al. Among authors: yang m. Eur J Immunol. 2008 May;38(5):1204-14. doi: 10.1002/eji.200838145. Eur J Immunol. 2008. PMID: 18412165 Free PMC article.
Sphingosine kinase 1 is a negative regulator of CD4+ Th1 cells.
Yang J, Castle BE, Hanidu A, Stevens L, Yu Y, Li X, Stearns C, Papov V, Rajotte D, Li J. Yang J, et al. J Immunol. 2005 Nov 15;175(10):6580-8. doi: 10.4049/jimmunol.175.10.6580. J Immunol. 2005. PMID: 16272312 Free article.
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