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Physiologically based mechanistic modelling to predict complex drug-drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut - the effect of diltiazem on the time-course of exposure to triazolam.
Rowland Yeo K, Jamei M, Yang J, Tucker GT, Rostami-Hodjegan A. Rowland Yeo K, et al. Among authors: yang j. Eur J Pharm Sci. 2010 Mar 18;39(5):298-309. doi: 10.1016/j.ejps.2009.12.002. Epub 2009 Dec 16. Eur J Pharm Sci. 2010. PMID: 20025966
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