Yang J - Search Results

1

Physiologically based mechanistic modelling to predict complex drug-drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut - the effect of diltiazem on the time-course of exposure to triazolam.

Rowland Yeo K, Jamei M, Yang J, Tucker GT, Rostami-Hodjegan A. Rowland Yeo K, et al. Among authors: yang j. Eur J Pharm Sci. 2010 Mar 18;39(5):298-309. doi: 10.1016/j.ejps.2009.12.002. Epub 2009 Dec 16. Eur J Pharm Sci. 2010. PMID: 20025966

2

Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions.

Yang J, Liao M, Shou M, Jamei M, Yeo KR, Tucker GT, Rostami-Hodjegan A. Yang J, et al. Curr Drug Metab. 2008 Jun;9(5):384-94. doi: 10.2174/138920008784746382. Curr Drug Metab. 2008. PMID: 18537575 Review.

3

Theoretical assessment of a new experimental protocol for determining kinetic values describing mechanism (time)-based enzyme inhibition.

Yang J, Jamei M, Yeo KR, Tucker GT, Rostami-Hodjegan A. Yang J, et al. Eur J Pharm Sci. 2007 Jul;31(3-4):232-41. doi: 10.1016/j.ejps.2007.04.005. Epub 2007 Apr 25. Eur J Pharm Sci. 2007. PMID: 17512176

4

Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA.

Yang J, Jamei M, Heydari A, Yeo KR, de la Torre R, Farré M, Tucker GT, Rostami-Hodjegan A. Yang J, et al. J Psychopharmacol. 2006 Nov;20(6):842-9. doi: 10.1177/0269881106065907. Epub 2006 May 19. J Psychopharmacol. 2006. PMID: 16714321

5

The effects of dose staggering on metabolic drug-drug interactions.

Yang J, Kjellsson M, Rostami-Hodjegan A, Tucker GT. Yang J, et al. Eur J Pharm Sci. 2003 Oct;20(2):223-32. doi: 10.1016/s0928-0987(03)00200-8. Eur J Pharm Sci. 2003. PMID: 14550889

6

Kinetic values for mechanism-based enzyme inhibition: assessing the bias introduced by the conventional experimental protocol.

Yang J, Jamei M, Yeo KR, Tucker GT, Rostami-Hodjegan A. Yang J, et al. Eur J Pharm Sci. 2005 Nov;26(3-4):334-40. doi: 10.1016/j.ejps.2005.07.005. Eur J Pharm Sci. 2005. PMID: 16137870

7

Prediction of intestinal first-pass drug metabolism.

Yang J, Jamei M, Yeo KR, Tucker GT, Rostami-Hodjegan A. Yang J, et al. Curr Drug Metab. 2007 Oct;8(7):676-84. doi: 10.2174/138920007782109733. Curr Drug Metab. 2007. PMID: 17979655 Review.

8

The Constraints, Construction, and Verification of a Strain-Specific Physiologically Based Pharmacokinetic Rat Model.

Musther H, Harwood MD, Yang J, Turner DB, Rostami-Hodjegan A, Jamei M. Musther H, et al. Among authors: yang j. J Pharm Sci. 2017 Sep;106(9):2826-2838. doi: 10.1016/j.xphs.2017.05.003. Epub 2017 May 8. J Pharm Sci. 2017. PMID: 28495566

9

Population-based mechanistic prediction of oral drug absorption.

Jamei M, Turner D, Yang J, Neuhoff S, Polak S, Rostami-Hodjegan A, Tucker G. Jamei M, et al. Among authors: yang j. AAPS J. 2009 Jun;11(2):225-37. doi: 10.1208/s12248-009-9099-y. Epub 2009 Apr 21. AAPS J. 2009. PMID: 19381840 Free PMC article. Review.

10

The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy).

Van LM, Heydari A, Yang J, Hargreaves J, Rowland-Yeo K, Lennard MS, Tucker GT, Rostami-Hodjegan A. Van LM, et al. Among authors: yang j. J Psychopharmacol. 2006 Nov;20(6):834-41. doi: 10.1177/0269881106062902. Epub 2006 Feb 14. J Psychopharmacol. 2006. PMID: 16478752

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