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Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity.
O'Brien C, Ling T, Berman JM, Culp-Hill R, Reisz JA, Rondeau V, Jahangiri S, St-Germain J, Macwan V, Astori A, Zeng A, Hong JY, Li M, Yang M, Jana S, Gamboni F, Tsao E, Liu W, Dick JE, Lin H, Melnick A, Tikhonova A, Arruda A, Minden MD, Raught B, D'Alessandro A, Jones CL. O'Brien C, et al. Among authors: yang m. Haematologica. 2023 Sep 1;108(9):2343-2357. doi: 10.3324/haematol.2022.281894. Haematologica. 2023. PMID: 37021547 Free PMC article.
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer.
Abril YLN, Fernandez IR, Hong JY, Chiang YL, Kutateladze DA, Zhao Q, Yang M, Hu J, Sadhukhan S, Li B, He B, Remick B, Bai JJ, Mullmann J, Wang F, Maymi V, Dhawan R, Auwerx J, Southard T, Cerione RA, Lin H, Weiss RS. Abril YLN, et al. Among authors: yang m. Oncogene. 2021 Mar;40(9):1644-1658. doi: 10.1038/s41388-020-01637-w. Epub 2021 Jan 21. Oncogene. 2021. PMID: 33479498 Free PMC article.
NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation.
Yu T, Hou D, Zhao J, Lu X, Greentree WK, Zhao Q, Yang M, Conde DG, Linder ME, Lin H. Yu T, et al. Among authors: yang m. Cell Rep. 2024 Apr 6;43(4):114070. doi: 10.1016/j.celrep.2024.114070. Online ahead of print. Cell Rep. 2024. PMID: 38583156 Free article.
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