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Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers.
Wang IM, Zhang B, Yang X, Zhu J, Stepaniants S, Zhang C, Meng Q, Peters M, He Y, Ni C, Slipetz D, Crackower MA, Houshyar H, Tan CM, Asante-Appiah E, O'Neill G, Luo MJ, Thieringer R, Yuan J, Chiu CS, Lum PY, Lamb J, Boie Y, Wilkinson HA, Schadt EE, Dai H, Roberts C. Wang IM, et al. Among authors: yang x. Mol Syst Biol. 2012 Jul 17;8:594. doi: 10.1038/msb.2012.24. Mol Syst Biol. 2012. PMID: 22806142 Free PMC article.
Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases.
Narayanan M, Huynh JL, Wang K, Yang X, Yoo S, McElwee J, Zhang B, Zhang C, Lamb JR, Xie T, Suver C, Molony C, Melquist S, Johnson AD, Fan G, Stone DJ, Schadt EE, Casaccia P, Emilsson V, Zhu J. Narayanan M, et al. Among authors: yang x. Mol Syst Biol. 2014 Jul 30;10(7):743. doi: 10.15252/msb.20145304. Mol Syst Biol. 2014. PMID: 25080494 Free PMC article.
11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.
Luo MJ, Thieringer R, Springer MS, Wright SD, Hermanowski-Vosatka A, Plump A, Balkovec JM, Cheng K, Ding GJ, Kawka DW, Koo GC, Grand CB, Luo Q, Maletic MM, Malkowitz L, Shah K, Singer I, Waddell ST, Wu KK, Yuan J, Zhu J, Stepaniants S, Yang X, Lum PY, Wang IM. Luo MJ, et al. Among authors: yang x. Physiol Genomics. 2013 Jan 7;45(1):47-57. doi: 10.1152/physiolgenomics.00109.2012. Epub 2012 Nov 20. Physiol Genomics. 2013. PMID: 23170035
Integrative network analysis reveals molecular mechanisms of blood pressure regulation.
Huan T, Meng Q, Saleh MA, Norlander AE, Joehanes R, Zhu J, Chen BH, Zhang B, Johnson AD, Ying S, Courchesne P, Raghavachari N, Wang R, Liu P; International Consortium for Blood Pressure GWAS (ICBP); O'Donnell CJ, Vasan R, Munson PJ, Madhur MS, Harrison DG, Yang X, Levy D. Huan T, et al. Among authors: yang x. Mol Syst Biol. 2015 Apr 16;11(1):799. doi: 10.15252/msb.20145399. Mol Syst Biol. 2015. PMID: 25882670 Free PMC article.
An integrative genomics approach to infer causal associations between gene expression and disease.
Schadt EE, Lamb J, Yang X, Zhu J, Edwards S, Guhathakurta D, Sieberts SK, Monks S, Reitman M, Zhang C, Lum PY, Leonardson A, Thieringer R, Metzger JM, Yang L, Castle J, Zhu H, Kash SF, Drake TA, Sachs A, Lusis AJ. Schadt EE, et al. Among authors: yang l, yang x. Nat Genet. 2005 Jul;37(7):710-7. doi: 10.1038/ng1589. Epub 2005 Jun 19. Nat Genet. 2005. PMID: 15965475 Free PMC article.
Variations in DNA elucidate molecular networks that cause disease.
Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE. Chen Y, et al. Among authors: yang x. Nature. 2008 Mar 27;452(7186):429-35. doi: 10.1038/nature06757. Epub 2008 Mar 16. Nature. 2008. PMID: 18344982 Free PMC article.
Identification and validation of genes affecting aortic lesions in mice.
Yang X, Peterson L, Thieringer R, Deignan JL, Wang X, Zhu J, Wang S, Zhong H, Stepaniants S, Beaulaurier J, Wang IM, Rosa R, Cumiskey AM, Luo JM, Luo Q, Shah K, Xiao J, Nickle D, Plump A, Schadt EE, Lusis AJ, Lum PY. Yang X, et al. J Clin Invest. 2010 Jul;120(7):2414-22. doi: 10.1172/JCI42742. Epub 2010 Jun 23. J Clin Invest. 2010. PMID: 20577049 Free PMC article.
Diurnal variation of the human adipose transcriptome and the link to metabolic disease.
Loboda A, Kraft WK, Fine B, Joseph J, Nebozhyn M, Zhang C, He Y, Yang X, Wright C, Morris M, Chalikonda I, Ferguson M, Emilsson V, Leonardson A, Lamb J, Dai H, Schadt E, Greenberg HE, Lum PY. Loboda A, et al. Among authors: yang x. BMC Med Genomics. 2009 Feb 9;2:7. doi: 10.1186/1755-8794-2-7. BMC Med Genomics. 2009. PMID: 19203388 Free PMC article.
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