Yang Y - Search Results

1

Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53.

Clement JA, Kitagaki J, Yang Y, Saucedo CJ, O'Keefe BR, Weissman AM, McKee TC, McMahon JB. Clement JA, et al. Among authors: yang y. Bioorg Med Chem. 2008 Dec 1;16(23):10022-8. doi: 10.1016/j.bmc.2008.10.024. Epub 2008 Oct 14. Bioorg Med Chem. 2008. PMID: 18977148 Free PMC article.

2

Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen.

Sasiela CA, Stewart DH, Kitagaki J, Safiran YJ, Yang Y, Weissman AM, Oberoi P, Davydov IV, Goncharova E, Beutler JA, McMahon JB, O'Keefe BR. Sasiela CA, et al. Among authors: yang y. J Biomol Screen. 2008 Mar;13(3):229-37. doi: 10.1177/1087057108315038. Epub 2008 Feb 12. J Biomol Screen. 2008. PMID: 18270365

3

Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.

Kitagaki J, Agama KK, Pommier Y, Yang Y, Weissman AM. Kitagaki J, et al. Among authors: yang y. Mol Cancer Ther. 2008 Aug;7(8):2445-54. doi: 10.1158/1535-7163.MCT-08-0063. Mol Cancer Ther. 2008. PMID: 18723490 Free PMC article.

4

Regulating the p53 system through ubiquitination.

Yang Y, Li CC, Weissman AM. Yang Y, et al. Oncogene. 2004 Mar 15;23(11):2096-106. doi: 10.1038/sj.onc.1207411. Oncogene. 2004. PMID: 15021897 Review.

5

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells.

Yang Y, Ludwig RL, Jensen JP, Pierre SA, Medaglia MV, Davydov IV, Safiran YJ, Oberoi P, Kenten JH, Phillips AC, Weissman AM, Vousden KH. Yang Y, et al. Cancer Cell. 2005 Jun;7(6):547-59. doi: 10.1016/j.ccr.2005.04.029. Cancer Cell. 2005. PMID: 15950904 Free article.

6

Expression and evaluation of RING finger proteins.

Yang Y, Lorick KL, Jensen JP, Weissman AM. Yang Y, et al. Methods Enzymol. 2005;398:103-12. doi: 10.1016/S0076-6879(05)98010-5. Methods Enzymol. 2005. PMID: 16275323

7

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

Yang Y, Kitagaki J, Dai RM, Tsai YC, Lorick KL, Ludwig RL, Pierre SA, Jensen JP, Davydov IV, Oberoi P, Li CC, Kenten JH, Beutler JA, Vousden KH, Weissman AM. Yang Y, et al. Cancer Res. 2007 Oct 1;67(19):9472-81. doi: 10.1158/0008-5472.CAN-07-0568. Cancer Res. 2007. PMID: 17909057

8

Studies of the ubiquitin proteasome system.

Lorick KL, Yang Y, Jensen JP, Iwai K, Weissman AM. Lorick KL, et al. Among authors: yang y. Curr Protoc Cell Biol. 2006 Jul;Chapter 15:Unit 15.9. doi: 10.1002/0471143030.cb1509s31. Curr Protoc Cell Biol. 2006. PMID: 18228479

9

Targeting the ubiquitin-proteasome system for cancer therapy.

Yang Y, Kitagaki J, Wang H, Hou DX, Perantoni AO. Yang Y, et al. Cancer Sci. 2009 Jan;100(1):24-8. doi: 10.1111/j.1349-7006.2008.01013.x. Epub 2008 Nov 24. Cancer Sci. 2009. PMID: 19037995 Free PMC article. Review.

10

DNA intercalator korkormicin A preferentially kills tumor cells expressing wild type p53.

Kitagaki J, Yang Y. Kitagaki J, et al. Among authors: yang y. Biochem Biophys Res Commun. 2011 Oct 14;414(1):186-91. doi: 10.1016/j.bbrc.2011.09.054. Epub 2011 Sep 16. Biochem Biophys Res Commun. 2011. PMID: 21946062

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