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A role for mitochondria in NLRP3 inflammasome activation.
Zhou R, Yazdi AS, Menu P, Tschopp J. Zhou R, et al. Nature. 2011 Jan 13;469(7329):221-5. doi: 10.1038/nature09663. Epub 2010 Dec 1. Nature. 2011. PMID: 21124315
Inflammasome activation in delayed-type hypersensitivity reactions.
Yazdi AS, Ghoreschi K, Röcken M. Yazdi AS, et al. J Invest Dermatol. 2007 Aug;127(8):1853-5. doi: 10.1038/sj.jid.5700815. J Invest Dermatol. 2007. PMID: 17632566
The cytosolic protein complex can be activated by danger signals, such as bacterial and viral components, ATP, or uric acid crystals, and reacts as a sensor of innate immunity. ...They are a prerequisite for the recruitment of cells into the skin that demand pro-inf …
The cytosolic protein complex can be activated by danger signals, such as bacterial and viral components, ATP, or uric acid crystals, …
The two faces of the inflammasome adaptor ASC in epithelial skin carcinogenesis.
Yazdi AS, Drexler SK. Yazdi AS, et al. Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 92):S94-6. Epub 2015 Oct 12. Clin Exp Rheumatol. 2015. PMID: 26457824 Review.
Silencing of ASC in Cutaneous Squamous Cell Carcinoma.
Meier K, Drexler SK, Eberle FC, Lefort K, Yazdi AS. Meier K, et al. PLoS One. 2016 Oct 21;11(10):e0164742. doi: 10.1371/journal.pone.0164742. eCollection 2016. PLoS One. 2016. PMID: 27768771 Free PMC article.
However, ASC is also known to trigger apoptosis in tumor cells, acting as a tumor-suppressor gene, which is lost in several human cancers. ...
However, ASC is also known to trigger apoptosis in tumor cells, acting as a tumor-suppressor gene, which is lost in several human can …
Complex roles of inflammasomes in carcinogenesis.
Drexler SK, Yazdi AS. Drexler SK, et al. Cancer J. 2013 Nov-Dec;19(6):468-72. doi: 10.1097/PPO.0000000000000004. Cancer J. 2013. PMID: 24270345 Review.
Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis.
Drexler SK, Bonsignore L, Masin M, Tardivel A, Jackstadt R, Hermeking H, Schneider P, Gross O, Tschopp J, Yazdi AS. Drexler SK, et al. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18384-9. doi: 10.1073/pnas.1209171109. Epub 2012 Oct 22. Proc Natl Acad Sci U S A. 2012. PMID: 23090995 Free PMC article.
However, mice fully deficient for ASC were not protected, and mice specifically deficient for ASC in keratinocytes developed more tumors than controls, suggesting that, in contrast to its proinflammatory role in myeloid cells, ASC acts as a tumor-suppressor in keratinocyte …
However, mice fully deficient for ASC were not protected, and mice specifically deficient for ASC in keratinocytes developed more tumors tha …
Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.
Gross O, Yazdi AS, Thomas CJ, Masin M, Heinz LX, Guarda G, Quadroni M, Drexler SK, Tschopp J. Gross O, et al. Immunity. 2012 Mar 23;36(3):388-400. doi: 10.1016/j.immuni.2012.01.018. Immunity. 2012. PMID: 22444631
Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders....
Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagoni …
Differential expression of NLRP3 among hematopoietic cells.
Guarda G, Zenger M, Yazdi AS, Schroder K, Ferrero I, Menu P, Tardivel A, Mattmann C, Tschopp J. Guarda G, et al. J Immunol. 2011 Feb 15;186(4):2529-34. doi: 10.4049/jimmunol.1002720. Epub 2011 Jan 21. J Immunol. 2011. PMID: 21257968
Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β.
Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, Tschopp J. Yazdi AS, et al. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19449-54. doi: 10.1073/pnas.1008155107. Epub 2010 Oct 25. Proc Natl Acad Sci U S A. 2010. PMID: 20974980 Free PMC article.
One application utilizes the opacifying effect of nano-TiO(2), which is frequently used as pigment in cosmetics. Although TiO(2) is believed to be biologically inert, an emerging literature reports increased incidence of respiratory diseases in people exposed to TiO(2). .. …
One application utilizes the opacifying effect of nano-TiO(2), which is frequently used as pigment in cosmetics. Although TiO(2) is b …
Inflammatory caspases in innate immunity and inflammation.
Yazdi AS, Guarda G, D'Ombrain MC, Drexler SK. Yazdi AS, et al. J Innate Immun. 2010;2(3):228-37. doi: 10.1159/000283688. Epub 2010 Feb 10. J Innate Immun. 2010. PMID: 20375549 Review.
Like their apoptotic counterparts, inflammatory caspases are produced as inactive zymogens and require activation to become proteolytically active. ...New functions have also been implicated, as these proteases and the mechanisms underlying their activation and regu …
Like their apoptotic counterparts, inflammatory caspases are produced as inactive zymogens and require activation to become proteolyt …
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