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Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action.
Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu LH, Li J, Ye JM. Turner N, et al. Among authors: ye jm. Diabetes. 2008 May;57(5):1414-8. doi: 10.2337/db07-1552. Epub 2008 Feb 19. Diabetes. 2008. PMID: 18285556
Activation of AMPK by bitter melon triterpenoids involves CaMKKβ.
Iseli TJ, Turner N, Zeng XY, Cooney GJ, Kraegen EW, Yao S, Ye Y, James DE, Ye JM. Iseli TJ, et al. Among authors: ye jm, ye y. PLoS One. 2013 Apr 25;8(4):e62309. doi: 10.1371/journal.pone.0062309. Print 2013. PLoS One. 2013. PMID: 23638033 Free PMC article.
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