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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. Boström P, et al. Among authors: Ye L. Nature. 2012 Jan 11;481(7382):463-8. doi: 10.1038/nature10777. Nature. 2012. PMID: 22237023 Free PMC article.
Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. Cohen P, et al. Among authors: Ye L. Cell. 2014 Jan 16;156(1-2):304-16. doi: 10.1016/j.cell.2013.12.021. Cell. 2014. PMID: 24439384 Free PMC article.
Fat cells directly sense temperature to activate thermogenesis.
Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP, Spiegelman BM. Ye L, et al. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12480-5. doi: 10.1073/pnas.1310261110. Epub 2013 Jul 1. Proc Natl Acad Sci U S A. 2013. PMID: 23818608 Free PMC article.
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.
Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. Ye L, et al. Cell. 2012 Sep 28;151(1):96-110. doi: 10.1016/j.cell.2012.08.034. Cell. 2012. PMID: 23021218 Free PMC article.
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.
Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM. Wu J, et al. Among authors: Ye L. Cell. 2012 Jul 20;150(2):366-76. doi: 10.1016/j.cell.2012.05.016. Epub 2012 Jul 12. Cell. 2012. PMID: 22796012 Free PMC article.
Development of insulin resistance in mice lacking PGC-1α in adipose tissues.
Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, Estall JL, Chatterjee Bhowmick D, Shulman GI, Spiegelman BM. Kleiner S, et al. Among authors: Ye L. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9635-40. doi: 10.1073/pnas.1207287109. Epub 2012 May 29. Proc Natl Acad Sci U S A. 2012. PMID: 22645355 Free PMC article.
Transcriptional control of preadipocyte determination by Zfp423.
Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM. Gupta RK, et al. Among authors: Ye L. Nature. 2010 Mar 25;464(7288):619-23. doi: 10.1038/nature08816. Epub 2010 Mar 3. Nature. 2010. PMID: 20200519 Free PMC article.
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex.
Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. Wu J, et al. Among authors: Ye L. Cell Metab. 2011 Feb 2;13(2):160-9. doi: 10.1016/j.cmet.2011.01.003. Cell Metab. 2011. PMID: 21284983 Free PMC article.
BRCA1 is a component of the RNA polymerase II holoenzyme.
Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD. Scully R, et al. Among authors: Ye L. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5605-10. doi: 10.1073/pnas.94.11.5605. Proc Natl Acad Sci U S A. 1997. PMID: 9159119 Free PMC article.
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